Testing Status of Agents at NTP
2,4-Diaminotoluene (2,4-toluene diamine)
CASRN: 95-80-7
Related: TRANSGENIC MODEL EVALUATION (2,4-DIAMINOTOLUENE)
Formula: C7-H10-N2
Synonyms/Common Names:
- 4-METHYL-1,3-BENZENEDIAMINE (9CI)
- 2,4-TOLUENE DIAMINE
Known Uses:
INTERMEDIATE FOR POLYURETHANES AND DYES; IN HAIR DYES (FORMERLY)
Short-Term Toxicity
- 13-WEEK (Dosed-Feed)
(C02302) Completed
- NTIS No. PB293593
(Peer Review 12/13/1978)
Citation: Bioassay of 2,4-Diaminotoluene for Possible Carcinogenicity (CAS No. 95-80-7) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,250,3000, M: 0,100,1000 PPM/5 PER GROUP
- NTIS No. PB293593
(Peer Review 12/13/1978)
Long-Term Carcinogenicity
- 2-YEAR (Dosed-Feed)
(C02302) Report Complete
- TR-162 (NTIS No. PB293593)
(Peer Review 12/13/1978)
Bioassay of 2,4-Diaminotoluene for Possible Carcinogenicity (CAS No. 95-80-7) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Negative
- Female Mice Positive
- Dose: MR: 0,79,176 (AVG), FR: 0,79,171 (AVG), M: 0,100,200 PPM/50 PER GROUP
- TR-162 (NTIS No. PB293593)
(Peer Review 12/13/1978)
Special Studies
- Cell Proliferation (Gavage)
(S0696) Completed
- Citation: CUNNINGHAM, M.L., FOLEY,J., MARONPOT, R.R., MATTHEWS, H.B. CORRELATION OF HEPATOCELLULAR PROLIFERATION WITH HEPATOCARCINOGENICITY INDUCED BY THE MUTAGENIC NONCARCINOGEN:CARCINOGEN PAIR - 2,6- & 2,4-DIAMINOTOLUENE TOXICOLOGY & APPLIED PHARM 107, 562-567 (1991)
- M Rats: F344/N
- Mechanisms (Intraperitoneal Injection)
(S0697) Completed
- Citation: CUNNINGHAM, M.L., & MATTHEWS, H.B. EVIDENCE FOR AN ACETOXYARYLAMINE AS THE ULTIMATE MUTAGENIC REACTIVE INTERMEDIATE OF THE CARCINOGENIC AROMATIC AMINE 2,4-DIAMINOTOLUENE, MUTATION RESEARCH, 242 (1990) 101-110
- M Rats: F344/N
- Mechanisms
(S0698) Completed
- Citation: CUNNINGHAM, M.L., BURKA, L.T., MATTHEWS, H.B., THE INTERACTION OF METHANOL, RAT-LIVERS S9 AND THE AROMATIC AMINE 2,4-DIAMINOTOLUENE PRODUCES A NEW MUTAGENIC COMPOUND: MUTATION RESEARCH, 244 (1990) 273-277
- M Rats: F344/N
- Metabolism
(S0699) Completed
- Citation: CUNNINGHAM, M.L., MATTHEWS, H.B., BURKA, L.T.: ACTIVATION OF METHANOL BY HEPATIC POSTMITOCHONDRIAL SUPERNATANT: FORMATION OF A CONDENSATION PROUDCT WITH 2,4-DIAMINOTOLUENE. CHEMICAL RESEARCH TOXICOLOGY, VOL3, #2 157-161, 1990.
- M Rats: F344/N
- Metabolism
(S0700) Completed
- Citation: FURLONG, B.B., WEAVER, R.P., & GOLDSTEIN, J.A. COVALENT BINDING TO DNA & MUTAGENICITY OF 2,4-DIAMINOTOLUENE METABOLITES PRODUCED BY ISOLATERD HEPATOCYTES AND 9000 G SUPERNATANT FROM FISCHER 344 RATS, CARCINOGENSIS VOL 8, #2 247-251, 1987
- M Rats: F344/N
- Other (Intraperitoneal Injection)
(S0701) Completed
- Citation: HAYWARD, J.J., SHANE, B.S. TINDALL, K.R., & CUNNINGHAM, M.L.: DIFFERENTIAL IN VIVO MUTAGENICITY OF THE CARCINOGEN/NON-CARCINGEN PAIR 2,4- & 2,6-DIAMINOTOLUENE: CARCINOGENESIS VOL 16 NO 10, PP 2429-2433, 1995
- M Mice: B6C3F1
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(314882) Completed
- Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Micronucleus
(520516) Completed
- Mice: B6C3F1
- Male Negative
- Micronucleus
(571690) Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(707834) Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Positive
Organ Systems Toxicity
- 14 DAY Immunotoxicity (Gavage)
(IMM87034) Completed
- F Mice: B6C3F1
- Dose: 0, 25, 50, 100 MG/KG
- Immunotoxicity (Topical Application)
(IMM92040) Completed
- F Mice: B6C3F1
- Dose: 0, 1, 3, 10%
- 8 CONS D (MTD PHASE), GD 7-14 (REPRO PHASE) Short-Term in vivo Repro. Tox. (Gavage)
(T0039) Completed
- NTIS No. PB84-183540
Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals - F Mice: Swiss
- Dose: 150 MG/KG BODY WT.
- NTIS No. PB84-183540
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