National Toxicology Program

CASRN: 94-52-0

Formula: C7-H5-N3-O2

Synonyms/Common Names:

• 5-NITRO-1H-BENZIMIDAZOLE (9CI)

Known Uses:

ANTIFOGGING AGENT IN PHOTOGRAPHIC DEVELOPER (HSDB 1990)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C01912) Completed 
  • NTIS No. PB293834  (Peer Review 10/25/1978)
    Citation: Bioassay of 6-Nitrobenzimidazole for Possible Carcinogenicity (CAS No. 94-52-0)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C01912) Completed 
  • NTIS No. PB293834  (Peer Review 10/25/1978)
    Citation: Bioassay of 6-Nitrobenzimidazole for Possible Carcinogenicity (CAS No. 94-52-0)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,0.08,0.16 %/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C01912) Report Complete 
  • TR-117 (NTIS No. PB293834)  (Peer Review 10/25/1978)
    Bioassay of 6-Nitrobenzimidazole for Possible Carcinogenicity (CAS No. 94-52-0)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R: 0,.12,.5, M: 0,.12,.24 %/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (753791) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (820174) Completed 
  • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Salmonella (NCI)  (CV-219) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive 
• Salmonella  (176359) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Positive