Testing Status of Agents at NTP
Michler's ketone
CASRN: 90-94-8
Formula: C17-H20-N2-O
Synonyms/Common Names:
- BIS (4-(DIMETHYLAMINO)PHENYL)-METHANONE (9CI)
- 4,4'-BIS(DIMETHYLAMINO)BENZOPHENONE
Known Uses:
DYE INTERMEDIATE
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C02006) Completed
- NTIS No. PB299855
(Peer Review 10/25/1978)
Citation: Bioassay of Michler's Ketone for Possible Carcinogenicity (CAS No. 90-94-8) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB299855
(Peer Review 10/25/1978)
- 13-Week (Dosed-Feed)
(C02006) Completed
- NTIS No. PB299855
(Peer Review 10/25/1978)
Citation: Bioassay of Michler's Ketone for Possible Carcinogenicity (CAS No. 90-94-8) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,680,14665, M: 0,440,13900 PPM/5 PER GROUP
- NTIS No. PB299855
(Peer Review 10/25/1978)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C02006) Report Complete
- TR-181 (NTIS No. PB299855)
(Peer Review 10/25/1978)
Bioassay of Michler's Ketone for Possible Carcinogenicity (CAS No. 90-94-8) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Positive
- Female Mice Positive
- Dose: MR: 0,250,500, FR: 0,500,1000, M: 0,1250,2500 PPM/50 PER GROUP
- TR-181 (NTIS No. PB299855)
(Peer Review 10/25/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(242025) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Not Tested
- In Vitro Cytogenetics (CA/SCE)
(913588) Completed
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Mouse Lymphoma (NCI)
(G29620) Completed
- Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
- Mouse Lymphoma-NCI Positive
- Mouse Lymphoma (NCI)
(G71544) Completed
- Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
- Mouse Lymphoma-NCI Positive
- Salmonella (NCI)
(N-9252) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Positive
- Salmonella
(635282) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Positive
Web page last updated on January 22, 2009