National Toxicology Program

CASRN: 90-43-7

Formula: C12-H10-O

Synonyms/Common Names:

• (1,1'-BIPHENYL)-2-OL (9CI)

Known Uses:

FUNGICIDE. GERMICIDE. HOUSEHOLD DISINFECTANT. PRESERVATIVE IN WATER-OIL EMULSIONS. DISH-WASHING FORMULATIONS.RUBBER INDUSTRY. PRODUCED FROM COAL TARS (TDB)

Short-Term Toxicity

• 14-Day (Topical Application)  (C50351) Completed 
  • NTIS No. PB86-217239  (Peer Review 03/29/1985)
    Citation: Toxicology and Carcinogenesis Studies of ORTHO-Phenylphenol (CAS No. 90-43-7) Alone and with 7,12-Dimethylbenz(a)anthracene (CAS No. 57-97-6) in Swiss CD-1 Mice (Dermal Studies)
  • Mice: Swiss

Long-Term Carcinogenicity

• 2-YEAR (Topical Application)  (C50351) Report Complete 
  • TR-301 (NTIS No. PB86-217239)  (Peer Review 03/29/1985)
    Toxicology and Carcinogenesis Studies of ORTHO-Phenylphenol (CAS No. 90-43-7) Alone and with 7,12-Dimethylbenz(a)anthracene (CAS No. 57-97-6) in Swiss CD-1 Mice (Dermal Studies)
  • Mice: Swiss
  • Carcinogenesis Results
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: 55.5 MG/0.1 ML/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (913440) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Weakly Positive 
• Drosophila  (589891) Completed 
  • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (550257) Completed 
  •  Positive 
• Mouse Lymphoma  (904368) Completed 
  •  Positive 
• Salmonella  (470644) Completed 
  •  Negative 
• Salmonella  (747588) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Weakly Positive