Testing Information

Testing Status of Agents at NTP

1-Phenyl-3-methyl-5-pyrazolone

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http://ntp.niehs.nih.gov/go/TS-10434-V

CASRN: 89-25-8

Formula: C10-H10-N2-0

Synonyms/Common Names:

  • 2,4-DIHYDRO-5-METHYL-2-PHENYL-3H-PYRAZOL-3-ONE (9CI)

Known Uses:

INTERMEDIATE FOR DYES AND DRUGS; LAB REAGENT

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03952) Completed 
    • NTIS No. PB287122  (Peer Review 06/29/1978)
      Citation: Bioassay of 1-Phenyl-3-methyl-5-pyrazolone for Possible Carcinogenicity (CAS No. 89-25-8)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03952) Completed 
    • NTIS No. PB287122  (Peer Review 06/29/1978)
      Citation: Bioassay of 1-Phenyl-3-methyl-5-pyrazolone for Possible Carcinogenicity (CAS No. 89-25-8)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,2150,21600, M: 0,2160,31600 PPM/10 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03952) Report Complete 
    • TR-141 (NTIS No. PB287122)  (Peer Review 06/29/1978)
      Bioassay of 1-Phenyl-3-methyl-5-pyrazolone for Possible Carcinogenicity (CAS No. 89-25-8)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,2500,5000, M: 0,7500,15000 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (837716) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Mouse Lymphoma  (216441) Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    •  Positive 
  • Salmonella (NCI)  (N-9242) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Negative 
  • Salmonella  (711054) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Negative 

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Web page last updated on January 22, 2009