National Toxicology Program

CASRN: 88-96-0

Formula: C8 H8 N2 O2

Synonyms/Common Names:

• 1,2-BENZENEDICARBOXAMIDE (9CI)

Known Uses:

INTERMEDIATE IN ORGANIC SYNTHESIS; LABORATORY REAGENT; INGREDIENT IN PAINT

Short-Term Toxicity

• 13-WEEK (Dosed-Feed)  (C03612) Completed 
  • NTIS No. PB293831  (Peer Review 12/13/1978)
    Citation: Bioassay of Phthalamide for Possible Carcinogenicity (CAS No. 88-96-0)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,6200,50000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C03612) Report Complete 
  • TR-161 (NTIS No. PB293831)  (Peer Review 12/13/1978)
    Bioassay of Phthalamide for Possible Carcinogenicity (CAS No. 88-96-0)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: MR: 0,15000,30000, FR: 0,5000,10000, MM: 0,25000,50000, FM: 0,6250,12500,25000 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (869808) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (472127) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Negative 
• Salmonella  (212698) Completed 
  • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
  •  Negative