National Toxicology Program

CASRN: 86-30-6

Formula: C12 H10 N2 O

Synonyms/Common Names:

• N-NITROSO-N-PHENYL-BENZENAMINE (9CI)

Known Uses:

ANTI-SCORCHING AGENT, INTERMEDIATE, STABILIZER, RUBBER ADDITIVE (HSDB 1990)

Short-Term Toxicity

• 13-WEEK (Dosed-Feed)  (C02880) Completed 
  • NTIS No. PB298275  (Peer Review 12/13/1978)
    Citation: Bioassay of N-Nitrosodiphenylamine for Possible Carcinogenicity (CAS No. 86-30-6)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: MR: 0,1000,10000, FR: 0,4000,46000, MM: 0,4250,22000, FM: 0,2200,46000 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C02880) Report Complete 
  • TR-164 (NTIS No. PB298275)  (Peer Review 12/13/1978)
    Bioassay of N-Nitrosodiphenylamine for Possible Carcinogenicity (CAS No. 86-30-6)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,1000,4000, MM: 0,10000,20000, FM: 0,2315,5741 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (672479) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (114324) Completed 
  •  Positive 
• Salmonella (NCI)  (N-9035) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escerichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1985) 1-251
  • Salmonella-NCI  Negative 
• Salmonella  (868421) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  •  Negative