National Toxicology Program

CASRN: 85-68-7

Formula: C19-H20-O4

Synonyms/Common Names:

• 1,2-BENZENEDICARBOXYLIC ACID, BUTYL PHENYLMETHYL ESTER (9CI)

Known Uses:

PLASTICIZER FOR PVC-BASED FLOORING PRODUCTS. ALSO USED IN BIODEGRADABLE TAMPON EJECTORS, ORGANIC INTERMEDIATE.

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C54375A) Completed 
  • NTIS No. PB83-118398  (Peer Review 06/23/1981)
    Citation: Carcinogenesis Bioassay of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C54375A) Completed 
  • NTIS No. PB83-118398  (Peer Review 06/23/1981)
    Citation: Carcinogenesis Bioassay of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,1600,25000 PPM/10 PER GROUP
• 26-WEEK (Dosed-Feed)  (C54375B) Completed 
  • NTIS No. PB98-131089
    Citation: Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344 Rats (Feed Studies)
  • Rats: F344/N
  • Dose: 0,.16,2.5 %/10 PER GROUP

Long-Term Carcinogenicity

• 109-WEEK (Dosed-Feed)  (C54375A) Report Complete 
  • TR-213 (NTIS No. PB83-118398)  (Peer Review 06/23/1981)
    Carcinogenesis Bioassay of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Inadequate Study 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,6000,12000 PPM/50 PER GROUP
• 2&3-YEAR (Dosed-Feed)  (C54375C) Report Complete 
  • TR-458 (NTIS No. PB98-131089)  (Peer Review 06/20/1995)
    Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344 Rats (Feed Studies)
  • Rats: F344/N; Rats: F344/N
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Equivocal Evidence 
  • Dose: MR: 0, .3%, .6%, OR 1.2%; 60/GROUP FR: 0, .6%, 1.2%, OR 2.4%; 60/GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous)  (S0049) Completed 
  • M Rats
  • Dose: 20 MG/KG
• Absorption Disposition Metabolism Elimination (Intravenous; Gavage)  (S0673) Completed 
  • Citation: EIGENBERG, D.A., BOZIGANM H.P., CARTER, D.E. & SIPES, I.G.: DISTRIBUTION, EXCRETION AND METABOLISM OF BUTYL BENZYL PHTHALATE IN THE RAT, JRNL TOX & ENVIR. HLTH, 17:445-456, 1986
  • Rats; Rats

Genetic Toxicology

• Chromosome Aberrations  (336452) Completed 
  • Mice
  • Chromosome Aberation  Positive 
• In Vitro Cytogenetics (CA/SCE)  (833451) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Drosophila  (312362) Completed 
  • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (811311) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Negative 
• Micronucleus  (A61034) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (834175) Completed 
  • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
  •  Negative 
• Salmonella  (933175) Completed 
  • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
  •  Negative 
• Sister Chromatid Exchanges  (336452) Completed 
  • Mice
  • Sister Chromatid  Positive 

Organ Systems Toxicity

• Continuous Breeding (Dosed-Feed)  (T0150B) Completed 
  • Rats: F344/N
• GD 6-15 Conventional Teratology (Dosed-Feed)  (TER88025) Completed 
  • NTIS No. PB90-115346
    Citation: Developmental Toxicity Evaluation of Butyl Benzyl Pthalate Administered in Feed to CD Rats on Gestational Days 6 to 15
  • F Rats: Sprague Dawley
  • Rats Maternal Positive 
  • Rats Fetal Positive 
  • Dose: 0.5, 1.25, 2.0%
• GD 6-15 Conventional Teratology (Dosed-Feed)  (TER89026) Completed 
  • NTIS No. PB91-129999
    Citation: Final Report on the Developmental Toxicity Evaluation of Butyl Benzyl Phthalate Administered in Feed to Swiss Albino (CD-1) Mice on Gestational Days 6 to 15
  • Citation: Final Report on the Developmental Toxicity Evaluation of Butyl Benzyl Phthalate Administered in Feed to Swiss Albino (CD-1) Mice on Gestational Days 6 to 15--Laboratory Supplement
  • F Mice: Swiss
  • Mice Maternal Positive 
  • Mice Fetal Positive 
  • Dose: 0.1, 0.5, 1.25. 2.0%