National Toxicology Program

CASRN: 85-44-9

Formula: C8-H4-O3

Synonyms/Common Names:

• 1,3-ISOBENZOFURANDIONE (9CI)

Known Uses:

RESINS; PLASTICIZERS; POLYESTERS; SYNTHESIS OF DYES; DRUG INTERMEDIATE; LAB REAGENT

Short-Term Toxicity

• 13-WEEK (Dosed-Feed)  (C03601) Completed 
  • NTIS No. PB293594  (Peer Review 12/13/1978)
    Citation: Bioassay of Phthalic Anhydride for Possible Carcinogenicity (CAS No. 85-44-9)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,6200,50000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C03601) Report Complete 
  • TR-159 (NTIS No. PB293594)  (Peer Review 12/13/1978)
    Bioassay of Phthalic Anhydride for Possible Carcinogenicity (CAS No. 85-44-9)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,7500,15000, MM: 0,16346,32692 (AVG), FM: 0,12019,24038 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (164933) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (358037) Completed 
  •  Positive 
• Salmonella  (050139) Completed 
  • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
  •  Negative 
• Salmonella  (648374) Completed 
  • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
  •  Negative