National Toxicology Program

CASRN: 82-28-0

Formula: C15 H11 N O2

Synonyms/Common Names:

• 1-AMINO-2-METHYL-9,10-ANTHRACENEDIONE (9CI)

Known Uses:

DYE INTERMEDIATE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C01901) Completed 
  • NTIS No. PB286852  (Peer Review 08/31/1978)
    Citation: Bioassay of 1-Amino-2-methylanthraquinone for Possible Carcinogenicity (CAS No. 82-28-0)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C01901) Completed 
  • NTIS No. PB286852  (Peer Review 08/31/1978)
    Citation: Bioassay of 1-Amino-2-methylanthraquinone for Possible Carcinogenicity (CAS No. 82-28-0)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,0.03,4.50 %/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C01901) Report Complete 
  • TR-111 (NTIS No. PB286852)  (Peer Review 08/31/1978)
    Bioassay of 1-Amino-2-methylanthraquinone for Possible Carcinogenicity (CAS No. 82-28-0)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Positive 
  • Dose: R: 0,.10,.20 (AVG), M: 0,0.6 (AVG) %/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (587359) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Salmonella  (217835) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive