Testing Information

Testing Status of Agents at NTP

Methyl methacrylate

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http://ntp.niehs.nih.gov/go/TS-10418-V

CASRN: 80-62-6

Formula: C5-H8-O2

Synonyms/Common Names:

  • 2-METHYL-2-PROPENOIC ACID METHYL ESTER (9CI)

Known Uses:

IN MANUF. OF METHACRYLATE RESINS & PLASTICS, IN IMPREGNATION OF CONCRETE, MONOMER.,COMONOMER, INTERMEDIATE, OCCURS IN OIL FROM ROMAN CHAMOMILE (MERCK 1989)

Short-Term Toxicity

  • 13-Week (Inhalation)  (C50680) Completed 
    • NTIS No. PB87-146742  (Peer Review 12/09/1985)
      Citation: Toxicology and Carcinogenesis Studies of Methyl Methacrylate (CAS No. 80-62-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,500,5000 PPM/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Inhalation)  (C50680) Report Complete 
    • TR-314 (NTIS No. PB87-146742)  (Peer Review 12/09/1985)
      Toxicology and Carcinogenesis Studies of Methyl Methacrylate (CAS No. 80-62-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: FR: 0,250,500, MR&M: 0,500,1000 PPM/50 PER GROUP

Special Studies

  • Cell Proliferation  (S0760) Completed 
    • Citation: GHANAYEM, B.I., MARONPOT, R.R. & MATTHEWS, H.B. ASSOCIATION OF CHEMICALLY INDUCED FORESTOMACH CELL PROLIFERATION AND CARCINOGENESIS. CANCER LETTERS, 32 (1986) 271-278
    • M Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (864485) Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (901631) Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (438144) Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    •  Positive 
  • Micronucleus  (011066) Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Micronucleus  (211002) Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Salmonella  (284726) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    •  Negative 
  • Salmonella  (683759) Completed 
    •  Weakly Positive 
  • Salmonella  (689062) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    •  Negative 

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Web page last updated on January 22, 2009