National Toxicology Program

CASRN: 78-34-2

Formula: C12-H26-O6-P2-S4

Synonyms/Common Names:

• PHOSPHORODITHIOIC ACID, S,S'-1,4-DIOXANE-2,3-DIYL O,O,O',O'-TETRAETHYL ESTER (9CI)

Known Uses:

INSECTICIDE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00395) Completed 
  • NTIS No. PB286185  (Peer Review 04/26/1978)
    Citation: Bioassay of Dioxathion for Possible Carcinogenicity (CAS No. 78-34-2)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00395) Completed 
  • NTIS No. PB286185  (Peer Review 04/26/1978)
    Citation: Bioassay of Dioxathion for Possible Carcinogenicity (CAS No. 78-34-2)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,21,464, M: 0,251,590 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00395) Report Complete 
  • TR-125 (NTIS No. PB286185)  (Peer Review 04/26/1978)
    Bioassay of Dioxathion for Possible Carcinogenicity (CAS No. 78-34-2)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: MR: 0,90,180 (AVG), FR: 0,45,90 (AVG), MM: 0,284,567 (AVG), FM: 0,467,937 (AVG) PPM/50 PER GROUP

Special Studies

• Cell Proliferation (Dosed-Feed)  (S0134) Completed 
  • Citation: CUNNINGHAM, ET. AL., RELATIONSHIP OF CARCINOGENICITY & CELLULAR PROLIFERATION INDUCED BY MUTAGENIC NONCARC VS CARC, FUND & APPL TOX 23, 363-369, 1994.
  • M Rats: F344/N
  • Dose: UP TO 400 PPM

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (472509) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (272327) Completed 
  •  Negative 
• Salmonella  (907385) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Positive