National Toxicology Program

CASRN: 76-87-9

Formula: C18 H16 O SN

Synonyms/Common Names:

• HYDROXYTRIPHENYLSTANNANE

Known Uses:

FUNGICIDE; ANTIFEEDING AGENT FOR INSECT CONTROL

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00260) Completed 
  • NTIS No. PB287399  (Peer Review 06/29/1978)
    Citation: Bioassay of Triphenyltin Hydroxide for Possible Carcinogenicity (CAS No. 76-87-9)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00260) Completed 
  • NTIS No. PB287399  (Peer Review 06/29/1978)
    Citation: Bioassay of Triphenyltin Hydroxide for Possible Carcinogenicity (CAS No. 76-87-9)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,100,464 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00260) Report Complete 
  • TR-139 (NTIS No. PB287399)  (Peer Review 06/29/1978)
    Bioassay of Triphenyltin Hydroxide for Possible Carcinogenicity (CAS No. 76-87-9)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,37.5,75 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (928563) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma (NCI)  (174971) Completed 
  • Mouse Lymphoma-NCI  Positive 
• Salmonella (NCI)  (N-9227) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Negative 
• Salmonella  (311380) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Negative