Testing Status of Agents at NTP
Bromodichloromethane
CASRN: 75-27-4
Formula: C-H-BR-CL2
Synonyms/Common Names:
- DICHLOROBROMOMETHANE
Known Uses:
SOLVENT. CHEMICAL INTERMEDIATE. FLAME RETARDANT. (TDB)
Short-Term Toxicity
- 14-Day (Gavage)
(C55243) Completed
- NTIS No. PB88-168687
(Peer Review 08/19/1986)
Citation: Toxicology and Carcinogenesis Studies of Bromodichloromethane (CAS No. 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB88-168687
(Peer Review 08/19/1986)
- 13-Week (Gavage)
(C55243) Completed
- NTIS No. PB88-168687
(Peer Review 08/19/1986)
Citation: Toxicology and Carcinogenesis Studies of Bromodichloromethane (CAS No. 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,19,300, MM: 0,6.25,100, FM: 0,25,400 MG/KG/10 PER GROUP
- NTIS No. PB88-168687
(Peer Review 08/19/1986)
Long-Term Carcinogenicity
- 108-WEEK (Gavage)
(C55243) Report Complete
- TR-321 (NTIS No. PB88-168687)
(Peer Review 08/19/1986)
Toxicology and Carcinogenesis Studies of Bromodichloromethane (CAS No. 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Mice: B6C3F1
- Carcinogenesis Results
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: R: 0,50,100 MM:0,25,50 FM: 0,75,150 MG/KG/50 PER GROUP
- TR-321 (NTIS No. PB88-168687)
(Peer Review 08/19/1986)
- 2-YEAR (Gavage)
(C55243) Report Complete
- TR-321 (NTIS No. PB88-168687)
(Peer Review 08/19/1986)
Toxicology and Carcinogenesis Studies of Bromodichloromethane (CAS No. 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Dose: R: 0,50,100 MM:0,25,50 FM: 0,75,150 MG/KG/50 PER GROUP
- TR-321 (NTIS No. PB88-168687)
(Peer Review 08/19/1986)
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage; Intravenous)
(S0097) Completed
- Citation: MATHEWS, J.M., TROXLER, P.S. & JEFFCOAT, A.R., METABOLISM & DISTRIBUTION OF BROMODICHLOROMETHANE IN RATS AFTER SINGLE & MULTIPLE ORAL DOSES, J TOXICOL & ENVIR HLTH, 30:15-22, 1990.
- M Rats: F344/N; M Rats: F344/N
- Dose: S:1,10,32,100; M:10,100 MG/KG X 10 DAYS
- Absorption Disposition Metabolism Elimination (Gavage)
(S0527) Completed
- M Rats: F344/N
- Dose: 1, 10, 32 & 100 MG/KG
- Toxicokinetic Study (Gavage)
(S0644) Completed
- Citation: REPORT IN DRAFT. IN REVIEW.
- M/F Rats: F344/N; M/F Mice: B6C3F1
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(494532) Completed
- Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
- Chromosome Aberation Negative
- Sister Chromatid Exchange Inconclusive
- Mouse Lymphoma
(173442) Completed
- Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
- Positive
- Micronucleus
(A08959) Completed
- Mice: Tg.AC (FVB/N) Hemizygous
- Male Inconclusive
- Female Negative
- Micronucleus
(A38548) Completed
- Mice: Tg.AC (FVB/N) Hemizygous
- Male Inconclusive
- Female Inconclusive
- Micronucleus
(A39408) Completed
- Mice: Tg.AC (FVB/N) Hemizygous
- Male Negative
- Female Negative
- Micronucleus
(A42280) Completed
- Mice: B6C3F1
- Male Negative
- Micronucleus
(A55870) Completed
- Mice: P53 +/- (C57BL/6)
- Male Negative
- Female Negative
- Micronucleus
(A78486) Completed
- Mice: B6C3F1
- Female Negative
- Micronucleus
(A90924) Completed
- Mice: P53 +/- (C57BL/6)
- Male Inconclusive
- Female Negative
- Salmonella
(038604) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
- Salmonella
(A68248) Completed
- Negative
Organ Systems Toxicity
- 35 DAYS Repro/Dev Gen Tox (28-Day) (Dosed-Water)
(RDGT94017) Completed
- NTIS No. PB99-111262
Citation: Short Term Reproductive and Developmental Toxicity of Bromodichloromethane (CAS #75-27-4) Administered in Drinking Water to Sprague-Dawley Rats - Rats: Sprague Dawley
- NTIS No. PB99-111262
Web page last updated on January 22, 2009