Testing Information

Testing Status of Agents at NTP

Bromodichloromethane

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http://ntp.niehs.nih.gov/go/TS-10397-Y

CASRN: 75-27-4

Formula: C-H-BR-CL2

Synonyms/Common Names:

  • DICHLOROBROMOMETHANE

Known Uses:

SOLVENT. CHEMICAL INTERMEDIATE. FLAME RETARDANT. (TDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55243) Completed 
    • NTIS No. PB88-168687  (Peer Review 08/19/1986)
      Citation: Toxicology and Carcinogenesis Studies of Bromodichloromethane (CAS No. 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55243) Completed 
    • NTIS No. PB88-168687  (Peer Review 08/19/1986)
      Citation: Toxicology and Carcinogenesis Studies of Bromodichloromethane (CAS No. 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,19,300, MM: 0,6.25,100, FM: 0,25,400 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 108-WEEK (Gavage)  (C55243) Report Complete 
    • TR-321 (NTIS No. PB88-168687)  (Peer Review 08/19/1986)
      Toxicology and Carcinogenesis Studies of Bromodichloromethane (CAS No. 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0,50,100 MM:0,25,50 FM: 0,75,150 MG/KG/50 PER GROUP
  • 2-YEAR (Gavage)  (C55243) Report Complete 
    • TR-321 (NTIS No. PB88-168687)  (Peer Review 08/19/1986)
      Toxicology and Carcinogenesis Studies of Bromodichloromethane (CAS No. 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
    • Dose: R: 0,50,100 MM:0,25,50 FM: 0,75,150 MG/KG/50 PER GROUP

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0097) Completed 
    • Citation: MATHEWS, J.M., TROXLER, P.S. & JEFFCOAT, A.R., METABOLISM & DISTRIBUTION OF BROMODICHLOROMETHANE IN RATS AFTER SINGLE & MULTIPLE ORAL DOSES, J TOXICOL & ENVIR HLTH, 30:15-22, 1990.
    • M Rats: F344/N; M Rats: F344/N
    • Dose: S:1,10,32,100; M:10,100 MG/KG X 10 DAYS
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0527) Completed 
    • M Rats: F344/N
    • Dose: 1, 10, 32 & 100 MG/KG
  • Toxicokinetic Study (Gavage)  (S0644) Completed 
    • Citation: REPORT IN DRAFT. IN REVIEW.
    • M/F Rats: F344/N; M/F Mice: B6C3F1

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (494532) Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Inconclusive 
  • Mouse Lymphoma  (173442) Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    •  Positive 
  • Micronucleus  (A08959) Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Inconclusive 
    • Female Negative 
  • Micronucleus  (A38548) Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Inconclusive 
    • Female Inconclusive 
  • Micronucleus  (A39408) Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A42280) Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A55870) Completed 
    • Mice: P53 +/- (C57BL/6)
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A78486) Completed 
    • Mice: B6C3F1
    • Female Negative 
  • Micronucleus  (A90924) Completed 
    • Mice: P53 +/- (C57BL/6)
    • Male Inconclusive 
    • Female Negative 
  • Salmonella  (038604) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (A68248) Completed 
    •  Negative 

Organ Systems Toxicity

  • 35 DAYS Repro/Dev Gen Tox (28-Day) (Dosed-Water)  (RDGT94017) Completed 
    • NTIS No. PB99-111262
      Citation: Short Term Reproductive and Developmental Toxicity of Bromodichloromethane (CAS #75-27-4) Administered in Drinking Water to Sprague-Dawley Rats
    • Rats: Sprague Dawley

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Web page last updated on January 22, 2009