Testing Information

Testing Status of Agents at NTP

Tribromomethane

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http://ntp.niehs.nih.gov/go/TS-10396-V

CASRN: 75-25-2

Formula: C-H-BR3

Synonyms/Common Names:

  • BROMOFORM

Known Uses:

SYNTHESIS OF PHARMACEUTICALS, IN SHIPBUILDING, AIRCRAFT INDUSTRY, IN FIRE-RESISTANT CHEMICALS, SEDATIVE MEDICATION, ANTITUSSIVE, ANTISEPTIC (HSDB 1990)

Short-Term Toxicity

  • 2-WEEK (Gavage)  (C55130) Completed 
    • NTIS No. PB90-110149  (Peer Review 04/18/1988)
      Citation: Toxicology and Carcinogenesis Studies of Tribromomethane (Bromoform) (CAS No. 75-25-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-WEEK (Gavage)  (C55130) Completed 
    • NTIS No. PB90-110149  (Peer Review 04/18/1988)
      Citation: Toxicology and Carcinogenesis Studies of Tribromomethane (Bromoform) (CAS No. 75-25-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,50,800 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C55130) Report Complete 
    • TR-350 (NTIS No. PB90-110149)  (Peer Review 04/18/1988)
      Toxicology and Carcinogenesis Studies of Tribromomethane (Bromoform) (CAS No. 75-25-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Clear Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&FM: 0,100,200, MM: 0,50,100 MG/KG/50 PER GROUP

Genetic Toxicology

  • Chromosome Aberrations  (244282) Completed 
    • Mice
    • Chromosome Aberation  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (845432) Completed 
    • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • In Vitro Cytogenetics (CA/SCE)  (973869) Completed 
    • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Weakly Positive 
  • Drosophila  (933572) Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (701597) Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    •  Positive 
  • Micronucleus  (244282) Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (312147) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Negative 
  • Salmonella  (445991) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Inconclusive 
  • Salmonella  (460994) Completed 
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Positive 
  • Salmonella  (871929) Completed 
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Inconclusive 
  • Sister Chromatid Exchanges  (244282) Completed 
    • Mice
    • Sister Chromatid  Positive 

Organ Systems Toxicity

  • 120 D MINIMUM Continuous Breeding (Gavage)  (RACB87111) Completed 
    • NTIS No. PB89-169254
      Citation: Bromoform Reproduction and Fertility Assessment in Swiss CD-1 Mice When Administered By Gavage
    • M/F Mice: Swiss
    • Dose: 0,50,100,200,400,800 MG/KG; 0,50,100,200 MG/KG; N/A; 0,200 MG/KG

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Web page last updated on January 22, 2009