National Toxicology Program

CASRN: 57-06-7

Formula: C4 H5 N S

Synonyms/Common Names:

• 3-ISOTHIOCYANATE-1-PROPENE (9CI)

Known Uses:

FLAVOR AGENT; IN BLACK MUSTARD SEED; IN CABBAGE FAMILY OF VEGETABLES

Short-Term Toxicity

• 14-Day (Gavage)  (C50464) Completed 
  • NTIS No. PB83-144238  (Peer Review 06/23/1981)
    Citation: Carcinogenesis Bioassay of Allyl Isothiocyanate (CAS No. 57-06-7) in F344/N Rats and B6C3F1 Mice (Gavage Study)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C50464) Completed 
  • NTIS No. PB83-144238  (Peer Review 06/23/1981)
    Citation: Carcinogenesis Bioassay of Allyl Isothiocyanate (CAS No. 57-06-7) in F344/N Rats and B6C3F1 Mice (Gavage Study)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,1.5,25 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C50464) Report Complete 
  • TR-234 (NTIS No. PB83-144238)  (Peer Review 06/23/1981)
    Carcinogenesis Bioassay of Allyl Isothiocyanate (CAS No. 57-06-7) in F344/N Rats and B6C3F1 Mice (Gavage Study)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Equivocal 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,12,25 MG/KG/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous)  (S0742) Completed 
  • Citation: IOANNOU, Y.M., BURKA, L.T., MATTHEWS, H.B.. ALLYL ISOTHIOCYANATE: COMPARATIVE DISPOSITION IN RATS AND MICE, TOXICOLOGY & APPLIED PHARMACOLOGY 75, 173-181 (1984)
  • M/F Rats: F344/N; M/F Mice: B6C3F1
  • Dose: 2.5 mg/kg, 25 mg/kg
• Metabolism (Gavage)  (S0743) Completed 
  • Citation: BORGHOFF, S.J., & BIRMBAUM, L.S. AGE-RELATED CHANGES IN THE METBOLSIM AND EXCRETION OF ALLYL ISOTHIOCYANATE. DRUG METABOLISM AND DISPOSITION, VOL 14, NO 4, 1986
  • M Rats: F344/N
  • Dose: 25 mg/kg

Genetic Toxicology

• Chromosome Aberrations  (056227) Completed 
  • Mice
  • Chromosome Aberation  Equivocal 
• Chromosome Aberrations  (A59578) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (630852) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (010317) Completed 
  • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (913948) Completed 
  • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (352025) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Micronucleus  (896173) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A41461) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A59578) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (521783) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Salmonella  (649249) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Weakly Positive 
• Sister Chromatid Exchanges  (056227) Completed 
  • Mice
  • Sister Chromatid  Positive