National Toxicology Program

CASRN: 56-72-4

Formula: C14 H16 CL O5 P S

Synonyms/Common Names:

• PHOSPHOROTHIOIC ACID, O-(3-CHLORO-4-METHYL-2-OXO-2H-1-BENZOPYRAN-7-YL)0,0-DIETHYL ESTER (9CI)

Known Uses:

LIVESTOCK INSECTICIDE WHICH FUNCTIONS SYSTEMICALLY BY ABSORPTION

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C08662) Completed 
  • NTIS No. PB290305  (Peer Review 10/25/1978)
    Citation: Bioassay of Coumaphos for Possible Carcinogenicity (CAS No. 56-72-4)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C08662) Completed 
  • NTIS No. PB290305  (Peer Review 10/25/1978)
    Citation: Bioassay of Coumaphos for Possible Carcinogenicity (CAS No. 56-72-4)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,320,640 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C08662) Report Complete 
  • TR-096 (NTIS No. PB290305)  (Peer Review 10/25/1978)
    Bioassay of Coumaphos for Possible Carcinogenicity (CAS No. 56-72-4)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,10,20 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (051728) Completed 
  • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (110131) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Negative 
• Salmonella (NCI)  (N-9276) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Negative 
• Salmonella  (342560) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Negative