Testing Information

Testing Status of Agents at NTP

Piperonyl butoxide

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http://ntp.niehs.nih.gov/go/TS-10358-W

CASRN: 51-03-6

Formula: C19-H30-O5

Synonyms/Common Names:

  • 5-((2-(2-BUTOXYETHOXY)ETHOXY)METHYL)-6-PROPYL-1,3-BENZODIOXOLE (9CI)

Known Uses:

SYNERGIST IN INSECTICIDES WITH PYRETHRINS

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02813) Completed 
    • NTIS No. PB288753  (Peer Review 08/31/1978)
      Citation: Bioassay of Piperonyl Butoxide for Possible Carcinogenicity (CAS No. 51-03-6)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02813) Completed 
    • NTIS No. PB288753  (Peer Review 08/31/1978)
      Citation: Bioassay of Piperonyl Butoxide for Possible Carcinogenicity (CAS No. 51-03-6)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,14700,6800, M: 0,4600,68000 PPM/5 PER GROUP

Long-Term Carcinogenicity

  • 109-WEEK (Dosed-Feed)  (C02813) Report Complete 
    • TR-120 (NTIS No. PB288753)  (Peer Review 08/31/1978)
      Bioassay of Piperonyl Butoxide for Possible Carcinogenicity (CAS No. 51-03-6)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,5000,10000, M: 0,1036,2804 (AVG) PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (593446) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Mouse Lymphoma  (374054) Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    •  Positive 
  • Salmonella  (408225) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

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Web page last updated on January 22, 2009