Testing Status of Agents at NTP
Phenylbutazone
CASRN: 50-33-9
Formula: C19-H20-N2-O2
Synonyms/Common Names:
- 4-BUTYL-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE (9CI)
Known Uses:
VETERINARY USE AS ANTI-INFLAMMATORY AGENT AND ANALGESIC. (TDB)
Short-Term Toxicity
- 2-WEEK (Gavage)
(C56531) Completed
- NTIS No. PB90-258765
(Peer Review 03/13/1989)
Citation: Toxicology and Carcinogenesis Studies of Phenylbutazone (CAS No. 50-33-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB90-258765
(Peer Review 03/13/1989)
- 13-WEEK (Gavage)
(C56531) Completed
- NTIS No. PB90-258765
(Peer Review 03/13/1989)
Citation: Toxicology and Carcinogenesis Studies of Phenylbutazone (CAS No. 50-33-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 25, 50, 100, 200, OR 300 MG/KG M: 0, 40, 80, 150, 300, OR 600 MG/KG
- NTIS No. PB90-258765
(Peer Review 03/13/1989)
Long-Term Carcinogenicity
- 2-YEAR (Gavage)
(C56531) Report Complete
- TR-367 (NTIS No. PB90-258765)
(Peer Review 03/13/1989)
Toxicology and Carcinogenesis Studies of Phenylbutazone (CAS No. 50-33-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats Some Evidence
- Male Mice Some Evidence
- Female Mice No Evidence
- Dose: R: 0, 50, 100, M: 0, 150, 300 MG/KG/50 PER GROUP
- TR-367 (NTIS No. PB90-258765)
(Peer Review 03/13/1989)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(534081) Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Chromosome Aberation Positive
- Sister Chromatid Exchange Negative
- Mouse Lymphoma
(421302) Completed
- Positive
- Micronucleus
(476079) Completed
- Mice: B6C3F1
- Male Negative
- Salmonella
(030078) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Web page last updated on January 22, 2009