National Toxicology Program

CASRN: 50-29-3

Formula: C14-H9-CL5

Synonyms/Common Names:

• BENZENE, 1,1'-(2,2,2-TRICHLOROETHYLIDENE)BIS(4-CHLORO- (9CI)
• CHLOROPHENOTHANE
• DDT

Known Uses:

INSECTICDE. PEDICULICIDE. (TDB)

Nomination Background

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00464) Completed 
  • NTIS No. PB286367  (Peer Review 06/29/1978)
    Citation: Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CAS No. 50-29-3, CAS No. 72-54-8, CAS No. 72-55-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00464) Completed 
  • NTIS No. PB286367  (Peer Review 06/29/1978)
    Citation: Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CAS No. 50-29-3, CAS No. 72-54-8, CAS No. 72-55-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,178,1780, M: 0,18,178 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00464) Report Complete 
  • TR-131 (NTIS No. PB286367)  (Peer Review 06/29/1978)
    Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CAS No. 50-29-3, CAS No. 72-54-8, CAS No. 72-55-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: MR: 0,321,642 (AVG), FR: 0,210,420 (AVG), MM: 0,22,44 (AVG), FM: 0,87,175 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (868203) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (836226) Completed 
  •  Negative 
• Salmonella  (873088) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Negative