National Toxicology Program

CASRN: 1314-62-1

Related: Vanadium dioxide

Formula: V2 O5

Synonyms/Common Names:

• VANADIUM OXIDE (9CI)

Known Uses:

CHEMICAL INTERMEDIATE. OXIDATION CATALYST IN INDUSTRIAL SYNTHESIS. ADDITIVE TO GLASS FOR SCREENING UV RADIATION. CERAMIC COLORING MATERIALS. PHOTOGRAPHIC DEVELOPER. DYEING TEXTILES. (TDB)

Nomination Background

Short-Term Toxicity

• 2-WEEK (Inhalation)  (C61427B) Completed 
  • NTIS No. PB2003102385  (Peer Review 10/18/2001)
    Citation: Toxicology and Carcinogenesis Studies of Vanadium Pentoxide (CAS No. 1314-62-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: FR: 0, 1, 2, OR 4 MG/M3 FM: 0, 2, 4, OR 8 MG/M3; 60/SPECIES/GROUP
• 2-WEEK (Inhalation)  (C61427) Completed 
  • NTIS No. PB2003102385
    Citation: Toxicology and Carcinogenesis Studies of Vanadium Pentoxide (CAS No. 1314-62-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0.0, 2.0, 4.0, 8.0, 16.0 OR 32.0 MG/M3 (5/S/S)
• 13-WEEK (Inhalation)  (C61427) Completed 
  • NTIS No. PB2003102385
    Citation: Toxicology and Carcinogenesis Studies of Vanadium Pentoxide (CAS No. 1314-62-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0.0, 1.0, 2.0, 4.0, 8.0, OR 16 MG/M3 (10/S/S)

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C61427B) Report Complete 
  • TR-507 (NTIS No. PB2003102385)  (Peer Review 10/18/2001)
    Toxicology and Carcinogenesis Studies of Vanadium Pentoxide (CAS No. 1314-62-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: R: 0, 0.5, 1, OR 2 MG/M3 M: 0, 1, 2, OR 4 MG/M3; 70/SEX/SPECIES/GROUP

Special Studies

• Toxicokinetic Study (Inhalation)  (S0607) Completed 
  • Citation: PART OF 14 DAY INHALATION SHORT TERM TOXICITY STUDY ABOVE
  • M/F Rats: F344/N; M/F Mice: B6C3F1
  • Dose: 14d: FR: 1, 2, 4 mg/m3; FM: 2, 4, 8 mg/m3 (report 08/96) 104w: R: 0.5, 1, 2 mg/m3; M: 1, 2, 4 mg/m3
• C. elegans  (S0962) Completed 
  • Nematode: C. elegans

Genetic Toxicology

• Micronucleus  (A59682) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (523108) Completed 
  •  Negative 

Organ Systems Toxicity

• Immunotoxicity (Inhalation)  (S0001) Completed 
  • Monkey