National Toxicology Program

CASRN: 97-77-8

Formula: C10 H20 N2 S4

Synonyms/Common Names:

• TETRAETHYLTHIOPEROXYDICARBONIC DIAMIDE :((H2N)C(S))2S2: (9CI)

Known Uses:

RUBBER ACCELERATOR, VULCANIZER; FUNGICIDE, SEED DISINFECTANT (MERCK 1989)

Short-Term Toxicity

• 2-WEEK (Dosed-Feed)  (C02959) Completed 
  • NTIS No. PB298514  (Peer Review 12/13/1978)
    Citation: Bioassay of Tetraethylthiuram Disulfide for Possible Carcinogenicity (CAS No. 97-77-8)
  • Rats: F344/N; Mice: B6C3F1
• 13-WEEK (Dosed-Feed)  (C02959) Completed 
  • NTIS No. PB298514  (Peer Review 12/13/1978)
    Citation: Bioassay of Tetraethylthiuram Disulfide for Possible Carcinogenicity (CAS No. 97-77-8)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,1500,6800, FM: 0,250,10000 PPM/5 PER GROUP - MM: 0,2000,8000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C02959) Report Complete 
  • TR-166 (NTIS No. PB298514)  (Peer Review 12/13/1978)
    Bioassay of Tetraethylthiuram Disulfide for Possible Carcinogenicity (CAS No. 97-77-8)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,300,600, MM: 0,500,2000, FM: 0,100,500 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (038371) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Negative 
• In Vitro Cytogenetics (CA/SCE)  (768765) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Not Tested 
• Mouse Lymphoma  (986702) Completed 
  • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
  •  Positive 
• Salmonella  (748370) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 

Organ Systems Toxicity

• GD 7-14 Short-Term in vivo Repro. Tox. (Gavage)  (T0044) Completed 
  • NTIS No. PB83-257600
    Citation: Screening of Priority Chemicals for Reproductive Hazards
  • F Mice: Swiss
  • Dose: 4900 MG/KG BODY WEIGHT