National Toxicology Program

CASRN: 6459-94-5

Formula: C37-H30-N4-O10-S3.2NA

Synonyms/Common Names:

• 8-((3,3'-DIMETHYL-4'-((4-(((4-METHYLPHENYL)SULFONYL)OXY)PHENYL)-AZO)(1,1'-BIPHENYL)-4-YL)AZO)-7-HYDROXY-1,3-NAPHTHALENEDISULFONIC ACID DISODIUM SALT
• RED 114, C.I. ACID

Known Uses:

DYE FOR SILK, JUTE FIBERS, WOOL, LEATHER. (TDB)

Short-Term Toxicity

• 14-Day (Dosed-Water)  (C61096) Completed 
  • NTIS No. PB92-189380  (Peer Review 03/11/1991)
    Citation: Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CAS No. 6459-94-5) in F344/N Rats (Drinking Water Studies)
  • Rats: F344/N
• 13-Week (Dosed-Water)  (C61096) Completed 
  • NTIS No. PB92-189380  (Peer Review 03/11/1991)
    Citation: Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CAS No. 6459-94-5) in F344/N Rats (Drinking Water Studies)
  • Rats: F344/N
  • Dose: 0, 600, 1200, 2500, 5000 PPM (10 PER GROUP)

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Water)  (C61096) Report Complete 
  • TR-405 (NTIS No. PB92-189380)  (Peer Review 03/11/1991)
    Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CAS No. 6459-94-5) in F344/N Rats (Drinking Water Studies)
  • Rats: F344/N
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Dose: MR: 0,70,150,300, FR: 0,150,300,600 PPM(70,45,75,70 PER GROUP RESPECTIVELY)

Special Studies

• Metabolism (Gavage; Dosed-Feed)  (S0023) Completed 
  • Citation: LYNN, RK, DONIELSON, DW, ILIAS, AM, KENNISH, JM, WONG,K & MATTHEWS, HB: METABOLISM OF BISAZOBIPHENYL DYES DERIVED FROM BENZIDINE, 3,3'-DIMETHYLBENZIDINE OR 3,3'-DIMETHOXYBENZIDINE TO CARCINOGENIC AROMATIC AMINES IN THE DOG & RAT. TOXICOL APPL PHARMACOL, 56:248-258,1980.
  • M Rats: Sprague Dawley; F Dog
  • Dose: DOGS: 100 MG/KG; RATS: 100 MG/KG

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (226009) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Drosophila  (668235) Completed 
  • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Salmonella  (831184) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Positive 
• Salmonella Reduction  (123112) Completed 
  • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
  •  Positive