National Toxicology Program

CASRN: 120-32-1

Formula: C13 H11 CL O

Synonyms/Common Names:

• 4-CHLORO-2-(PHENYLMETHYL)-PHENOL (9CI)

Known Uses:

GERMICIDE IN DISINFECTANT SOLUTIONS AND SOAP. (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C61201A) Completed 
  • NTIS No. PB94-214202
    Citation: Toxicology and Carcinogenesis Studies of o-Benzyl-p-Chlorophenol (CAS No. 120-32-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 3-WEEK (Topical Application)  (C61201B) Completed 
  • NTIS No. PB96-162342  (Peer Review 11/17/1993)
    Citation: Initiation/Promotion Study ofo-Benzyl-p-Chlorophenol (CAS No.120-32-1) in Swiss (CD-1®) Mice (Mouse Skin Study)
  • Mice: Swiss CD-1
• 13-Week (Gavage)  (C61201A) Completed 
  • NTIS No. PB94-214202
    Citation: Toxicology and Carcinogenesis Studies of o-Benzyl-p-Chlorophenol (CAS No. 120-32-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,30,480 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 1-YEAR (Topical Application)  (C61201B) Report Complete 
  • TR-444 (NTIS No. PB96-162342)  (Peer Review 11/17/1993)
    Initiation/Promotion Study ofo-Benzyl-p-Chlorophenol (CAS No.120-32-1) in Swiss (CD-1®) Mice (Mouse Skin Study)
  • Mice: Swiss CD-1
  • Dose: ACETONE CONTROL, DMBA/DMBA, DMBA/ACETONE, DMBA/TPA, DMBA/BCP(1,10,30 MG/ML), TPA/TPA, BCP(10)/TPA, BCP/BCP, BCP(10)/BCP(1,10,30)
• 2-YEAR (Gavage)  (C61201C) Report Complete 
  • TR-424 (NTIS No. PB94-214202)  (Peer Review 12/01/1992)
    Toxicology and Carcinogenesis Studies of o-Benzyl-p-Chlorophenol (CAS No. 120-32-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Some Evidence 
  • Female Mice No Evidence 
  • Dose: MR: 0,30,60,120, FR: 0,60,120,240, M: 0,120,240,480 MG/KG/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous; Gavage; Topical Application)  (S0070) Completed 
  • Citation: KAO AND BIRNBAUM. DISPOSITION OF O-BENZYL-P-CHLOROPHENOL IN MALE RATS. JOURNAL OF TOXICOLOGY & ENVIRONMENTAL HEALTH, 18: 441-458, 1986
  • M Rats: F344/N; M Rats: F344/N; M Rats
  • Dose: 10,100,1000:GAV 10 MG/KG:IV

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (353016) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Salmonella  (284925) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Salmonella  (845798) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 

Organ Systems Toxicity

• Immunotoxicity (Topical Application)  (IMM89037) Completed 
  • F Mice: B6C3F1
  • Dose: SENSITIZATION: 0,1,3,10%; CHALLENGE: 30%; POSITIVE CONTROL (DNFB) 0.5%.
• Neurotoxicology Assessment (Gavage)  (NTA94016) Completed 
  • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
  • M/F Rats/Mice: F344/N