Testing Information

Testing Status of Agents at NTP

Tricresyl phosphate

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http://ntp.niehs.nih.gov/go/TS-10277-D

CASRN: 1330-78-5

Formula: C21 H21 O4 P

Synonyms/Common Names:

  • PHOSPHORIC ACID, TRIS(METHYLPHENYL)ESTER (9CI)

Known Uses:

PLASTICIZER, FIRE RETARDANT FOR PLASTICS, HEAT EXCHANGE & AIR FILTER MEDIUM, WATERPROOFING, HYDRAULIC FLUID, LEAD SCAVENGER IN GASOLINE (MERCK 1989)

Nomination Background

Short-Term Toxicity

  • 14-Day (Gavage)  (C61041A) Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C61041A) Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,50,800 MG/KG/10 PER GROUP
  • 13-Week (Dosed-Feed)  (C61041B) Completed 
    • NTIS No. PB95-227377  (Peer Review 06/22/1993)
      Citation: Toxicology and Carcinogenesis Studies of Tricresyl Phosphate (CAS No. 1330-78-5) in F344/N Rats and B6C3F1 Mice (Gavage and Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,900,1300, M: 0,250,4200 PPM/5 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C61041B) Report Complete 
    • TR-433 (NTIS No. PB95-227377)  (Peer Review 06/22/1993)
      Toxicology and Carcinogenesis Studies of Tricresyl Phosphate (CAS No. 1330-78-5) in F344/N Rats and B6C3F1 Mice (Gavage and Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0,75,150,300,600, M: 0,60,125,250 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (272835) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Salmonella  (197511) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (618410) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 120 D MINIMUM Continuous Breeding (Dosed-Feed)  (RACB84114) Completed 
    • NTIS No. PB86-167277
      Citation: Tricresyl Phosphate: Reproduction and Fertility Assessment In CD-1 Mice When Administered In the Feed
    • M/F Mice: Swiss
    • Dose: N/A; 0,.05,.1,.2%; N/A; N/A

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Web page last updated on January 22, 2009