National Toxicology Program

CASRN: 396-01-0

Formula: C12 H11 N7

Synonyms/Common Names:

• 6-PHENYL-2,4,7-PTERIDINETRIAMINE (9CI)

Known Uses:

DIURETIC AND NATRIURETIC AGENT. (TDB)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C56042A) Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C56042A) Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,150,2400, M: 0,100,1600 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C56042B) Report Complete 
  • TR-420 (NTIS No. PB94-213782)  (Peer Review 11/21/1991)
    Toxicology and Carcinogenesis Studies of Triamterene (CAS No. 396-01-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal Evidence 
  • Female Rats No Evidence 
  • Male Mice Some Evidence 
  • Female Mice Some Evidence 
  • Dose: R: 0,150,300,600, M: 0,100,200,400 PPM RESTART MICE: 0,400 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (695685) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Salmonella  (190695) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Salmonella  (303754) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative