Testing Status of Agents at NTP
Methyleugenol
CASRN: 93-15-2
Formula: C11 H14 O2
Synonyms/Common Names:
- 1,2-DIMETHOXY-4-(2-PROPENYL)BENZENE
Known Uses:
FLAVORING AGENT IN FOODS AND BEVERAGES; AS A FRAGRANCE IN COSMETICS; AS AN INSECT ATTRACTANT IN ERADICATION PROGRAMS AND AS AN ANESETHETIC IN RODENTS.
Short-Term Toxicity
- 2-WEEK (Gavage)
(C60991) Completed
- NTIS No. PB2000-107865
Citation: Toxicology and Carcinogenesis Studies of Methyleugenol (CAS No. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 10000, 20000 AND 40000 PPM/ RATS: 10 MALE, 5 FEMALE/GROUP; MICE: 5/SEX/GROUP
- NTIS No. PB2000-107865
- 13-WEEK (Gavage)
(C60991) Completed
- NTIS No. PB2000-107865
Citation: Toxicology and Carcinogenesis Studies of Methyleugenol (CAS No. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,10,30,100,300,1000 MG/KG PLUS SHAM GAVAGE GROUP
- NTIS No. PB2000-107865
Long-Term Carcinogenicity
- 2-YEAR (Gavage)
(C60991B) Report Complete
- TR-491 (NTIS No. PB2000-107865)
(Peer Review 10/30/1998)
Toxicology and Carcinogenesis Studies of Methyleugenol (CAS No. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: R&M: 0, 37, 75, OR 150 MG/KG; 50/SEX/SPECIES/GROUP
- TR-491 (NTIS No. PB2000-107865)
(Peer Review 10/30/1998)
Special Studies
- Absorption Disposition Metabolism Elimination (in-vitro)
(K10265) On Test
- Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Gavage)
(S0844) Completed
- Citation: FINAL REPORT: CHEMICAL DISPOSITION IN MAMMALS, 03/15/98 - 06/30/99. I.G. SIPES. J.L. BURKEY, M.J. KATTNIG. DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, CENTER FOR TOXICOLOGY, COLLEGE OF PHARMACY, THE UNIVERSITY OF ARIZONA, TUCSON, ARIZONA 85721. IN VIVO AND IN IN VITRO METABOLISM, DISPOSITION, AND COVALENT BINDING OF METHYLEUGENOL.
- M Rats: F344/N; M Rats: F344/N; F Mice: B6C3F1
- Dose: 118 mg/kg, 50 uCi/kg gavage; 11.8 mg/kg, 120 uCi/kg intravenously; 118 mg/kg, 50 uCi/kg gavage
- Metabolism (in-vitro)
(S0658) Completed
- Citation: CYTOTOXICITY & GENOTOXICITY OF METHYLEUGENOL & RELATED CONGENERS - A MECHANISM OF ACTIVATION FOR METHYLEUGENOL.
- M/F Rats; M/F Mice; M/F Human
- Metabolism
(S0898) Completed
- Citation: FINAL REPORT: CHEMICAL DISPOSITION IN MAMMALS, 03/15/98 - 06/30/99. I.G. SIPES. J.L. BURKEY, M.J. KATTNIG. DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, CENTER FOR TOXICOLOGY, COLLEGE OF PHARMACY, THE UNIVERSITY OF ARIZONA, TUCSON, ARIZONA 85721. IN VITRO STUDIES WITH METHYLEUGENOL AND COMPARISONS WITH RELATED COMPOUNDS.
- F Mice: B6C3F1; M Rats: F344/N; Human
- Other
(S0826) Completed
- Citation: CYTOTOXICITY AND GENOTOXICITY OF METHYLEUGENOL AND RELATED CONGENERS-A MECHANISM OF ACTIVATION FOR METHYLEUGENOL. J.L. BURKEY, J-M SAUER, C.A. MCQUEEN, I.G. SIPES. MUTATION RESEARCH 453 (2000) 25-33. FUN-DAMENTALS & MOLECULAR MECHANISMS OF MUTAGENESIS. KEYWORDS: CYTOTOXICITY; GENOTOXICITY; METHYLEUGENOL.
- Toxicokinetic Study (Gavage)
(S0577) Completed
- Citation: SEE TECHNICAL REPORT 491
- M/F Rats: F344/N; M/F Mice: B6C3F1
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(614248) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- Micronucleus
(A29699) Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(690169) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Organ Systems Toxicity
- GD 6 TO 19 Conventional Teratology (Gavage)
(TER97007) Completed
- NTIS No. PB2004-104348
Citation: DEVELOPMENTAL TOXICITY EVALUATION FOR METHYLEUGENOL (CAS NO. 93-15-2) ADMINISTERED BY GAVAGE TO SPRAGUE-DAWLEY (CD(r)) RATS ON GESTATIONAL DAYS 6 THROUGH 19 - NTIS No. PB2004-104349
Citation: DEVELOPMENTAL TOXICITY EVALUATION FOR METHYLEUGENOL (CAS NO. 93-15-2) ADMINISTERED BY GAVAGE TO SPRAGUE-DAWLEY (CD(r)) RATS ON GESTATIONAL DAYS 6 THROUGH 19 (Laboratory Supplement) - F Rats: Sprague Dawley
- Dose: 0, 80, 200, OR 500 MG/KG/DAY
- NTIS No. PB2004-104348
- GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)
(TRP92045) Completed
- F Rats: Sprague Dawley
- Dose: 0, 300, 600, 800, 1000, OR 1200 MG/KG
- GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)
(TRP92046) Completed
- F Rabbit: New Zealand White
- Dose: 0, 100, 400, 600, 800, OR 1000 MG/KG
- GD 6-19 Teratology Pilot Studies (Gavage)
(TRP97007) Completed
- F Rats: Sprague Dawley
- Dose: 0, 31.25, 62.5, 125, 250, OR 500 MG/KG/DAY
Web page last updated on January 22, 2009