Testing Status of Agents at NTP
Isobutyraldehyde
CASRN: 78-84-2
Formula: C4 H8 O
Synonyms/Common Names:
- 2-METHYLPROPANAL (9CI)
Known Uses:
SYNTHESIS OF PANTOTHENIC ACID, CELLULOSE ESTERS, PERFUMES, FLAVORS, AND GASOLINE ADDITIVES. CHEMICAL INTERMEDIATE. (TDB)
Short-Term Toxicity
- 14-Day (Inhalation)
(C60968A) Completed
- NTIS No. PB99-134785
Citation: Toxicology and Carcinogenesis Studies of Isobutyraldehyde (CAS No. 78-84-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB99-134785
- 13-Week (Inhalation)
(C60968A) Completed
- NTIS No. PB99-134785
Citation: Toxicology and Carcinogenesis Studies of Isobutyraldehyde (CAS No. 78-84-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,500,8000 PPM/10 PER GROUP
- NTIS No. PB99-134785
Long-Term Carcinogenicity
- 2-YEAR (Inhalation)
(C60968B) Report Complete
- TR-472 (NTIS No. PB99-134785)
(Peer Review 12/12/1996)
Toxicology and Carcinogenesis Studies of Isobutyraldehyde (CAS No. 78-84-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R&M: 0, 500, 1000, OR 2000 PPM (50/SEX/SPECIES/GROUP)
- TR-472 (NTIS No. PB99-134785)
(Peer Review 12/12/1996)
Genetic Toxicology
- Chromosome Aberrations
(A27944) Completed
- Mice
- Chromosome Aberation Positive
- In Vitro Cytogenetics (CA/SCE)
(984070) Completed
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Drosophila
(112954) Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Mouse Lymphoma
(927534) Completed
- Positive
- Micronucleus
(A56966) Completed
- Rats: F344
- Male Negative
- Micronucleus
(A60444) Completed
- Mice: B6C3F1
- Male Negative
- Micronucleus
(A73413) Completed
- Mice: B6C3F1
- Male Negative
- Salmonella
(700142) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
- Salmonella
(941876) Completed
- Inconclusive
Organ Systems Toxicity
- Immunotoxicity (Topical Application)
(IMM87038) Completed
- F Mice: B6C3F1
- Dose: SENSITIZATION: 0,3,10,30%; CHALLENGE: 30%; POSITIVE CONTROL: 0.5% DNFB.
Web page last updated on January 22, 2009