National Toxicology Program

CASRN: 23246-96-0

Formula: C18-H23-N-O6

Synonyms/Common Names:

• RIDDELLINE
• SENECIONAN-11,16-DIONE, 13,19-DIDEHYDRO-12,18-DIHYDROXY- (9CI)

Known Uses:

NATURALLY OCCURRING PHARMACEUTICAL AGENT

Short-Term Toxicity

• 2-WEEK (Gavage)  (C61358B) Completed 
  • TOX-27 (NTIS No. PB94-194685)  (Peer Review 06/24/1992)
    Toxicity Studies of Riddelliine (CAS No. 23246-96-0) Administered by Gavage to F344 Rats and B6C3F1Mice.
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M:0,0.33,1.0,3.3,10.0,25.0 MG/KG (5/S/S)
• 13-WEEK (Gavage)  (C61358B) Report Complete 
  • TOX-27 (NTIS No. PB94-194685)  (Peer Review 06/24/1992)
    Toxicity Studies of Riddelliine (CAS No. 23246-96-0) Administered by Gavage to F344 Rats and B6C3F1Mice.
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R:0,0.1,0.33,1.0,3.3,10.0 MG/KG; M:0,0.33,1.0,3.3,10.0,25.0 MG/KG (10/S/S)

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C61358C) Report Complete 
  • TR-508 (NTIS No. PB2003-106432)  (Peer Review 10/18/2001)
    Toxicology and Carcinogenesis Studies of Riddelliine (CAS No. 23246-96-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: MR: 0 OR 1.0 MG/KG; 50/DOSE FR: 0, 0.01, 0.033, 0.1, 0.33, OR 1.0 MG/KG; 62/DOSE MM: 0, 0.1, 0.3, 1.0, OR 3.0 MG/KG; 50/DOSE FM: 0 OR 3.0 MG/KG; 50/DOSE

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (762742) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Micronucleus  (A52780) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (532340) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive