National Toxicology Program

CASRN: 10101-97-0

Formula: Ni-O4-S.6H2-O

Synonyms/Common Names:

• SULFURIC ACID, NICKEL(2+) SALT (1:1), HEXAHYDRATE (9CI)

Known Uses:

NICKEL PLATING. BLACKENING ZINC AND BRASS. MORDANT IN DYEING. (1)

Short-Term Toxicity

• 2-WEEK (Inhalation)  (C60344) Completed 
  • NTIS No. PB97-120216  (Peer Review 11/29/1994)
    Citation: Toxicology and Carcinogenesis Studies of Nickel Sulfate Hexahydrate (CAS No. 10101-97-0) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 3.5, 7.0, 15.0, 30.0, OR 60.0 MG/M3; 5/GROUP
• 13-WEEK (Inhalation)  (C60344) Completed 
  • NTIS No. PB97-120216  (Peer Review 11/29/1994)
    Citation: Toxicology and Carcinogenesis Studies of Nickel Sulfate Hexahydrate (CAS No. 10101-97-0) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.12, 0.25, 0.50, 1.0, OR 2.0 MG/M3

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C60344) Report Complete 
  • TR-454 (NTIS No. PB97-120216)  (Peer Review 11/29/1994)
    Toxicology and Carcinogenesis Studies of Nickel Sulfate Hexahydrate (CAS No. 10101-97-0) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0, 0.125, 0.25, OR 0.5 M: 0, .25, .5, OR 1.0 MG/M3; 50/GROUP

Genetic Toxicology

• Mouse Lymphoma  (411811) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Salmonella  (A45391) Completed 
  •  Negative