National Toxicology Program

CASRN: 87-62-7

Formula: C8 H11 N

Synonyms/Common Names:

• 2,6-DIMETHYLBENZENAMINE (9CI)

Known Uses:

CHEMICAL INTERMEDIATE FOR DYES. (TDB)

Short-Term Toxicity

• 10&14-WK (Dosed-Feed)  (C56188B) Completed 
  • NTIS No. PB90-256363  (Peer Review 09/22/1982)
    Citation: Toxicology and Carcinogenesis Studies of 2,6-Xylidine (2,6-Dimethylaniline) (CAS No. 87-62-7) in Charles River CD Rats (Feed Studies)
  • Rats: CD
  • Dose: SD(GAV):0.215,0.316, 0.681,1,1.47,2.15, 3.16 MG/KG IN CORN OIL/ 5 PER GROUP; SC (FEED): 0,100,300, 1000,3000,10000 PPM (MALES 10 WKS, FEMALES 14 WKS)

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C56188B) Report Complete 
  • TR-278 (NTIS No. PB90-256363)  (Peer Review 09/22/1982)
    Toxicology and Carcinogenesis Studies of 2,6-Xylidine (2,6-Dimethylaniline) (CAS No. 87-62-7) in Charles River CD Rats (Feed Studies)
  • Rats: CD
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Dose: 0,300,1000,3000 PPM/56 ANIMALS PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (852885) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (538744) Completed 
  • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (976601) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Salmonella  (112391) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Weakly Positive 
• Salmonella  (593478) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Weakly Positive 
• Salmonella  (818172) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative