National Toxicology Program

CASRN: 1300-72-7

Formula: C8 H9 O3 S.NA

Synonyms/Common Names:

• DIMETHYLBENZENESULFONIC ACID SODIUM SALT (9CI)
• XYLENE SULFONIC ACID, NA SALT

Known Uses:

HYDROTROPE IN LIQUID DETERGENTS, SHAMPOOS, DEGREASING COMPOUNDS. USED IN TEXTILE, PAPER, AND LEATHER INDUSTRIES. (TDB)

Short-Term Toxicity

• 3-WEEK (Topical Application)  (C55403C) Completed 
  • NTIS No. PB98-168719
    Citation: Toxicology and Carcinogenesis Studies of Technical Grade Sodium Xylene Sulfonate (CAS No. 1300-72-7) in F344 Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-WEEK (Topical Application)  (C55403C) Completed 
  • NTIS No. PB98-168719
    Citation: Toxicology and Carcinogenesis Studies of Technical Grade Sodium Xylene Sulfonate (CAS No. 1300-72-7) in F344 Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 120.0,39.9,13.2,4.5,1.5,0 MG/KG

Long-Term Carcinogenicity

• 2-YEAR (Topical Application)  (C55403D) Report Complete 
  • TR-464 (NTIS No. PB98-168719)  (Peer Review 12/05/1995)
    Toxicology and Carcinogenesis Studies of Technical Grade Sodium Xylene Sulfonate (CAS No. 1300-72-7) in F344 Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0, 60, 120, OR 240 MG/KG M: 0, 182, 364, OR 727 MG/KG (50/SEX/GROUP)

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (344381) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (779152) Completed 
  •  Inconclusive 
• Salmonella  (994691) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative