Testing Information

Testing Status of Agents at NTP

tris(2-Chloroethyl) phosphate

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http://ntp.niehs.nih.gov/go/TS-10178-C

CASRN: 115-96-8

Formula: C6 H12 CL3 O4 P

Synonyms/Common Names:

  • 2-CHLOROETHANOL PHOSPHATE (3:1) (9CI)

Known Uses:

FLAME RETARDANT. PLASTICIZER. (TDB)

Short-Term Toxicity

  • 2-WEEK (Gavage)  (C60128) Completed 
    • NTIS No. PB92-105147  (Peer Review 04/25/1990)
      Citation: Toxicology and Carcinogenesis Studies of Tris(2-chloroethyl) Phosphate (CAS No. 115-96-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-WEEK (Gavage)  (C60128) Completed 
    • NTIS No. PB92-105147  (Peer Review 04/25/1990)
      Citation: Toxicology and Carcinogenesis Studies of Tris(2-chloroethyl) Phosphate (CAS No. 115-96-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,22,350; M: 0,44,700 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C60128) Report Complete 
    • TR-391 (NTIS No. PB92-105147)  (Peer Review 04/25/1990)
      Toxicology and Carcinogenesis Studies of Tris(2-chloroethyl) Phosphate (CAS No. 115-96-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R: 0,44,88; M: 0,175,350 MG/KG/60 PER GROUP

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0183) Completed 
    • Citation: DISPOSITION OF TRIS(2-CHLOROETHYL) PHOSPHATE (TRCP) IN RATS AFTER ORAL ADMINISTRATION, MARCH, 1988
    • M Rats: F344/N
    • Dose: 88 MG/KG
  • Absorption Disposition Metabolism Elimination  (S0723) Completed 
    • Citation: HERR, D.W., SANDERS, J.M., & MATTHEWS, H.B., BRAIN DISTRIBUTION AND FATE OF TRIS(2-CHLOROETHYL) PHOSPHATE IN FISCHER 344 RATS DRUG METABOLISM AND DISPOSITION, VOL 19, NO. 2, 436-442 (1991).
    • M/F Rats: F344/N
  • Metabolism (Gavage)  (S0107) Completed 
    • Citation: BURKA, L.T., SANDERS, J.M., HERR, D.W. & MATTHEWS, H.B.: METABOLISM OF TRIS(2-CHLOROETHYL) PHOSPHATE IN RATS & MICE, DRUG MET & DISPO, 19(2): 443-447, 1991.
    • M Rats: F344/N; M Mice: B6C3F1
    • Dose: 175 MG/KG
  • Metabolism  (S0724) Completed 
    • Citation: CHAPMAN, D.E., MICHENER, S.R., POWIS, G, METABOLISM OF THE FLAME RETARDANT PLASTICIZER TRIS(2-CHLOROETHYL) PHOSPHATE BY HUMAN AND RAT LIVER PREPARATIONS. FUNDAMENTAL & APPLIED TOXICOLOGY 17, 215-224 (1991)
    • Rats: F344/N; Human
  • Other (Gavage)  (S0495) Completed 
    • Citation: MATTHEWS, ET. AL., ACUTE EXPOSURE TO ... PRODUCES HIPPOCAMPAL NEURONAL LOSS & IMPAIRS LEARNING IN RATS, TOXICOL & APPL PHARM 106:254-269,1990.
    • F Rats: F344/N
    • Dose: 275 MG/KG
  • Other  (S0725) Completed 
    • Citation: DETERDING, L.J., DIX, K., BURKA, L.T. & TOMER, K.B., ON-LINE COUPLING OF IN VIVO MICRODIALYSIS WITH TANDEM MASS SPECTROMETRY ANALYTICAL CHEMISTRY, NOV. 1, 1992, PP. 2636-2641.
    • M Rats: F344/N
  • Other  (S0823) Completed 
    • Citation: SPECIAL STUDY ON SERUM CHOLINESTERASE LEVELS DURING THE 90-DAY SUBCHRNOIC TOXICITY TEST (C60128) IN FISCHER 344 RATS
    • Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (616376) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Inconclusive 
  • Salmonella  (639784) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • > 120 DAYS Continuous Breeding (Gavage)  (RACB92040) Completed 
    • NTIS No. PB92-129170
      Citation: Final Report on the Reproductive Toxicity of Tris(2-Chloroethyl)phosphate in CD-1 Swiss Mice
    • M/F Mice: Swiss
    • Dose: 0,87.5,175,350,700,1000; 0,175,350,700 MG/KG/DAY; 0,700 MG/KG/DAY; 0,175,350,700 MG/KG/DAY
  • GD 7-14 Short-Term in vivo Repro. Tox. (Gavage)  (T0085) Completed 
    • NTIS No. PB85-220143
      Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • F Mice: Swiss
    • Dose: 940 MG/KG BODY WT

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Web page last updated on January 22, 2009