Testing Information

Testing Status of Agents at NTP

Trichloroethylene

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http://ntp.niehs.nih.gov/go/TS-10175-P

CASRN: 79-01-6

Formula: C2 H CL3

Synonyms/Common Names:

  • TRICHLOROETHENE (9CI)

Known Uses:

DEGREASER, DRY CLEANING SOLVENT, MANUF. ORG. CHEMICALS & PHARMACEUTICALS, HEAT EXCHANGE LIQUID, DILUENT IN PAINTS & ADHESIVES, CAFFEINE EXTRACTANT, TEXTILE PROCESSING, SOLVENT IN PROD'N OF COLOR ADDITIVES FOR FOOD, COSMETICS, DRUGS (HSDB 1990)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04546A) Completed 
    • NTIS No. PB264122  (Peer Review NA)
      Citation: Carcinogenesis Bioassay of Trichloroethylene (CAS No. 79-01-6)
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 4-WEEK (Dosed-Feed)  (C04546G) Completed 
    • Rats: F344/N
  • 4-WEEK (Gavage)  (C04546H) Completed 
    • Rats: F344/N
  • 13-Week (Gavage)  (C04546A) Completed 
    • NTIS No. PB264122  (Peer Review NA)
      Citation: Carcinogenesis Bioassay of Trichloroethylene (CAS No. 79-01-6)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0,562,5620, M: 0,1000,10000 MG/KG/5 PER GROUP
  • 13-Week (Gavage)  (C04546B) Completed 
    • NTIS No. PB88-218896  (Peer Review 08/19/1986)
      Citation: Toxicology and Carcinogenesis Studies of Trichloroethylene (CAS No. 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
    • Rats: August; Rats: ACI
    • Dose: MR: 0,125,2000, FR: 0,62.5,1000 MG/KG/10 PER GROUP
  • 13-Week (Gavage)  (C04546C) Completed 
    • NTIS No. PB88-218896  (Peer Review 08/19/1986)
      Citation: Toxicology and Carcinogenesis Studies of Trichloroethylene (CAS No. 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
    • Rats: Marshall; Rats: Osborne Mendel
    • Dose: RB:MR: 0,268,1834, FR: 0,134,918 MG/KG/10 PER GROUP
  • 13-Week (Gavage)  (C04546E) Completed 
    • NTIS No. PB91-111815  (Peer Review 09/22/1982)
      Citation: Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CAS No. 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR: 0,125,2000, FR: 0,62.5,1000, M: 0,375,6000 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04546A) Report Complete 
    • TR-002 (NTIS No. PB264122)  (Peer Review NA)
      Carcinogenesis Bioassay of Trichloroethylene (CAS No. 79-01-6)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,549,1097 MM: 0,1169,2339 FM: 0,869,1739 MG/KG/50 PER GROUP
  • 107-WEEK (Gavage)  (C04546B) Report Complete 
    • TR-273 (NTIS No. PB88-218896)  (Peer Review 08/19/1986)
      Toxicology and Carcinogenesis Studies of Trichloroethylene (CAS No. 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
    • Rats: ACI
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
    • Dose: 0,500,1000 MG/KG/50 PER GROUP
  • 2-YEAR (Gavage)  (C04546B) Report Complete 
    • TR-273 (NTIS No. PB88-218896)  (Peer Review 08/19/1986)
      Toxicology and Carcinogenesis Studies of Trichloroethylene (CAS No. 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
    • Rats: August
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
    • Dose: 0,500,1000 MG/KG/50 PER GROUP
  • 2-YEAR (Gavage)  (C04546C) Report Complete 
    • TR-273 (NTIS No. PB88-218896)  (Peer Review 08/19/1986)
      Toxicology and Carcinogenesis Studies of Trichloroethylene (CAS No. 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
    • Rats: Marshall; Rats: Osborne Mendel
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
    • Dose: 0,500,1000 MG/KG/50 PER GROUP
  • 121-WEEK (Gavage)  (C04546E) Report Complete 
    • TR-243 (NTIS No. PB91-111815)  (Peer Review 09/22/1982)
      Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CAS No. 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,500,1000, M: 0,1000 MG/KG/50 PER GROUP

Special Studies

  • Absorption Disposition Metabolism Elimination (Intraperitoneal Injection; Dosed-Water)  (S0061) Completed 
    • M Rats: F344/N; M Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (316661) Completed 
    • Mice
    • Chromosome Aberation  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (365766) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (389288) Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive 
  • Mouse Lymphoma  (114328) Completed 
    •  Positive 
  • Mouse Lymphoma  (623351) Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    •  Positive 
  • Micronucleus  (679194) Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (536227) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (574937) Completed 
    •  Negative 
  • Sister Chromatid Exchanges  (316661) Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 

Organ Systems Toxicity

  • 14 DAYS Immunotoxicity (Gavage)  (IMM20006) Completed 
    • F Mice: B6C3F1
    • Dose: 0, 50, 75, 100, 150, 200, 250, 300, 350, 400, 500, OR 800 MG/KG
  • 14 DAYS Immunotoxicity (Gavage)  (IMM20008) Completed 
    • M Mice: Swiss CD-1
    • Dose: 0, 125, 250, OR 500 MG/KG
  • 56 DAYS Immunotoxicity (Gavage)  (IMM96007) Completed 
    • F Rats: Brown-Norway
    • Dose: 0 OR 500 MG/KG/DAY
  • 56 DAYS Immunotoxicity (Gavage)  (IMM97002) Completed 
    • F Rats: Brown-Norway
    • Dose: 0, 100, 200, OR 400 MG/KG/DAY
  • 14 DAYS Immunotoxicity (Gavage)  (IMM98010) Completed 
    • F Mice: B6C3F1
    • Dose: 0, 50, 75, 100, 150, 200, 250, 300, 350, 400, 500, OR 800 MG/KG
  • >20 D MINIMUM Continuous Breeding (Dosed-Feed)  (RACB84112) Completed 
    • NTIS No. PB86-190782
      Citation: Trichloroethylene: Reproduction And Fertility Assessment In F344 Rats When Administered In the Feed
    • M/F Rats: F344/N
    • Dose: 0,.6,1.2,2.4,3.61,4.82%; 0,.15,.3,.6%; 0,.6%; 0,.15,.3,.6%
  • 120 D MINIMUM Continuous Breeding (Dosed-Feed)  (RACB84113) Completed 
    • NTIS No. PB86-173150
      Citation: Trichloroethylene: Reproduction and Fertility Assessment In CD-1 Mice When Administered in the Feed
    • M/F Mice: Swiss
    • Dose: 0,.6,1.2,2.4,3.61,4,82%; 0,.15,.3,.6%; N/A; 0,.6%

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Web page last updated on January 22, 2009