National Toxicology Program

CASRN: 1271-19-8

Formula: C10 H10 CL2 TI

Synonyms/Common Names:

• DICHLOROBIS(ETA(5)-2,4-CYCLOPENTADIEN-1-YL)-TITANIUM (9CI)

Known Uses:

RESEARCH CHEMICAL. CATALYST. (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C04502) Completed 
  • NTIS No. PB92-129576/AS  (Peer Review 11/19/1990)
    Citation: Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CAS No. 1271-19-8) in F344/N Rats (Gavage Studies)
  • Rats: F344/N
• 13-Week (Gavage)  (C04502) Completed 
  • NTIS No. PB92-129576/AS  (Peer Review 11/19/1990)
    Citation: Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CAS No. 1271-19-8) in F344/N Rats (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0,.008,.125 G/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C04502) Report Complete 
  • TR-399 (NTIS No. PB92-129576/AS)  (Peer Review 11/19/1990)
    Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CAS No. 1271-19-8) in F344/N Rats (Gavage Studies)
  • Rats: F344/N
  • Carcinogenesis Results
  • Male Rats Equivocal Evidence 
  • Female Rats Equivocal Evidence 
  • Dose: RATS ONLY:0,25,50 MG/KG/80 PER GROUP

Special Studies

• Toxicokinetic Study  (S0269) Completed 
  • M Rats: F344/N

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (241636) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Salmonella (NCI)  (N-9026) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escerichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1985) 1-251
  • Salmonella-NCI  Negative 
• Salmonella  (813172) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  •  Positive