National Toxicology Program

CASRN: 13463-67-7

Formula: O2 TI

Synonyms/Common Names:

• C.I. PIGMENT WHITE 6
• TITANIUM OXIDE (9CI)

Known Uses:

WHITE PIGMENT IN PAINTS, COATINGS, PAPER, PLASTICS, DRUGS, COSMETICS, FOOD INDUSTRY, CAPACITORS, ANTICORROSIVE AGENTS; WELDING ROD COATINGS & METAL PRODUCTION, FOUND IN NATURE AS MINERAL RUTILE (HSDB 1989)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C04240) Completed 
  • NTIS No. PB288780  (Peer Review 08/13/1978)
    Citation: Bioassay of Titanium Dioxide for Possible Carcinogenicity (CAS No. 13463-67-7)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C04240) Completed 
  • NTIS No. PB288780  (Peer Review 08/13/1978)
    Citation: Bioassay of Titanium Dioxide for Possible Carcinogenicity (CAS No. 13463-67-7)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,6250,100000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C04240) Report Complete 
  • TR-097 (NTIS No. PB288780)  (Peer Review 08/13/1978)
    Bioassay of Titanium Dioxide for Possible Carcinogenicity (CAS No. 13463-67-7)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,25000,50000 PPM/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (860815) Completed 
  • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (766516) Completed 
  • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in Vitro IV: Results for l5 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Drosophila  (211708) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (006080) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Negative 
• Micronucleus  (563272) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Positive 
• Salmonella (NCI)  (CV-22) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Negative 
• Salmonella  (004554) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Negative 
• Sister Chromatid Exchanges  (860815) Completed 
  • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol)