Testing Status of Agents at NTP
Tetrahydrofuran
CASRN: 109-99-9
Formula: C4 H8 O
Synonyms/Common Names:
- 1,4-EPOXYBUTANE
Known Uses:
REACTION MEDIUM FOR GRIGNARD AND METAL HYDRIDE REACTIONS. PACKAGING FABRICATION. SOLVENT FOR RESINS AND PLASTICS. CHEMICAL INTERMEDIATE. (TDB)
Short-Term Toxicity
- 14-Day (Gavage)
(C60560A) Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Gavage)
(C60560A) Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,125,2000, M: 0,63,1000 MG/KG/10 PER GROUP
- 13-WEEK (Inhalation)
(C60560B) Completed
- NTIS No. PB98-164544
Citation: Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CAS No. 109-99-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0,66,200,600,1800,5000 PPM
- NTIS No. PB98-164544
Long-Term Carcinogenicity
- 2-YEAR (Inhalation)
(C60560C) Report Complete
- TR-475 (NTIS No. PB98-164544)
(Peer Review 12/11/1996)
Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CAS No. 109-99-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Some Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice Clear Evidence
- Dose: R&M: 0, 200, 600, OR 1800 PPM (50/SEX/SPECIES/GROUP)
- TR-475 (NTIS No. PB98-164544)
(Peer Review 12/11/1996)
Genetic Toxicology
- Chromosome Aberrations
(720076) Completed
- Mice
- Chromosome Aberation Negative
- In Vitro Cytogenetics (CA/SCE)
(378945) Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Chromosome Aberation Negative
- Sister Chromatid Exchange Negative
- Drosophila
(442740) Completed
- Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Micronucleus
(A34612) Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Inconclusive
- Female Negative
- Salmonella
(551903) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
- Salmonella
(620162) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
- Sister Chromatid Exchanges
(720076) Completed
- Mice
- Sister Chromatid Positive (Nonstandard Protocol)
Organ Systems Toxicity
- GD 6 - 17 FOR MICE Conventional Teratology (Inhalation)
(TER88047) Completed
- Citation: DE89001383/LL
- F Rats/Mice: Sprague Dawley/Swiss
- Rats/Mice Maternal Positive
- Rats/Mice Fetal Positive
- Dose: 600, 1800, 5000 PPM
- GD 6 - 19 Conventional Teratology (Inhalation)
(TER88139) Completed
- Citation: DE89001313/LL
- F Rats: Sprague Dawley
- Dose: 0, 600, 1800, 5000 PPM
Web page last updated on January 22, 2009