National Toxicology Program

CASRN: 14807-96-6

Formula: H2 O3 SI.3/4MG

Known Uses:

DUSTING POWDER FOR MEDICINAL AND COSMETIC PREPARATIONS. EXCIPIENT AND FILLER FOR PILLS. USED BY RUBBER, PAINT, FOOD, ASPHALT, AND PAPER INDUSTRIES. IMPROVES THERMOFORCED FOOD PACKAGING. OCCURS NATURALLY.

Short-Term Toxicity

• 14-Day (Inhalation)  (C06008) Completed 
  • NTIS No. PB94-215985  (Peer Review 06/23/1992)
    Citation: Toxicology and Carcinogenesis Studies of Talc (CAS No. 14807-96-6)(Non-Asbestiform) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C06008) Report Complete 
  • TR-421 (NTIS No. PB94-215985)  (Peer Review 06/23/1992)
    Toxicology and Carcinogenesis Studies of Talc (CAS No. 14807-96-6)(Non-Asbestiform) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Clear Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R & M: 0, 6, AND 18 MG OF TALC/M3 OF ATMOSPHERE