Testing Status of Agents at NTP
Styrene
CASRN: 100-42-5
Formula: C8 H8
Synonyms/Common Names:
- ETHENYLBENZENE (9CI)
- PHENYLETHYLENE
- VINYLBENZENE
Known Uses:
IN MANUFACTURE OF PLASTICS, SYNTHETIC RUBBER, RESINS. INSULATOR. USED IN CONSTRUCTION MATERIALS AND BOATS. CHEMICAL INTERMEDIATE. FLAVORING AGENT. (TDB)
Short-Term Toxicity
- 14-Day (Gavage)
(C02200A) Completed
- NTIS No. PB300977
(Peer Review 10/25/1978)
Citation: Bioassay of Styrene for Possible Carcinogenicity (CAS No.100-42-5) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB300977
(Peer Review 10/25/1978)
- 2-WEEK (Inhalation)
(C02200B) Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 30, 100, 300, 1000, 0R 2000 PPM (5/S/S)
- 13-Week (Gavage)
(C02200A) Completed
- NTIS No. PB300977
(Peer Review 10/25/1978)
Citation: Bioassay of Styrene for Possible Carcinogenicity (CAS No.100-42-5) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,681,3160, M: 0,147,681 MG/KG/10 PER GROUP
- NTIS No. PB300977
(Peer Review 10/25/1978)
- 13-WEEK (Inhalation)
(C02200B) Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 125, 250, 500, 1000, OR 1500 PPM M: 0, 62.5, 125, 250, OR 500 PPM
Long-Term Carcinogenicity
- 2-Year (Gavage)
(C02200A) Report Complete
- TR-185 (NTIS No. PB300977)
(Peer Review 10/25/1978)
Bioassay of Styrene for Possible Carcinogenicity (CAS No.100-42-5) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Equivocal
- Female Mice Negative
- Dose: R: 0,500,1000,2000, M: 0,150,300 MG/KG/50 PER GROUP
- TR-185 (NTIS No. PB300977)
(Peer Review 10/25/1978)
Special Studies
- Mechanisms (Inhalation)
(S0333) Completed
- Citation: MORGAN ET AL. STYRENE INHALATION TOXICITY STUDIES IN MICE. 1 HEPATOTOXICITY IN B6C3F1 MICE, FUND & APPL TOXICOL 20:325-335, 1993. 2. SEX DIFFERENCES IN SUSCEPTIBILITY OF B6C3F1 MICE, FUND & APPL TOXICOL 21:317-325, 1993. 3. STRAIN DIFFERENCES IN SUSCEPTIBILITY, FUND & APPL TOXICOL 21:326-333, 1993.
- M/F Mice: B6C3F1; M/F Mice: C57BL/6; M/F Mice: Swiss; M/F Mice
- Dose: 125, 250 OR 500 PPM
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(987609) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Negative
- Micronucleus
(A71890) Completed
- Male Not Tested
- Female Not Tested
- Micronucleus
(A82713) Completed
- Male Positive
- Salmonella (NCI)
(N-9246) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Negative
- Salmonella
(173117) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Negative
Web page last updated on January 22, 2009