Testing Information

Testing Status of Agents at NTP

Probenecid

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http://ntp.niehs.nih.gov/go/TS-10160-L

CASRN: 57-66-9

Formula: C13-H19-N-O4-S

Synonyms/Common Names:

  • 4-((DIPROPYLAMINO)SULFONYL)BENZOIC ACID (9CI)

Known Uses:

URICOSURIC AGENT FOR TREATMENT OF GOUT AND GOUTY ARTHRITIS. (TDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C56097) Completed 
    • NTIS No. PB92-129584/AS  (Peer Review 11/20/1990)
      Citation: Toxicology and Carcinogenesis Studies of Probenecid (CAS No. 57-66-9) in F344/N Rats and B6C3F1 Mice(Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56097) Completed 
    • NTIS No. PB92-129584/AS  (Peer Review 11/20/1990)
      Citation: Toxicology and Carcinogenesis Studies of Probenecid (CAS No. 57-66-9) in F344/N Rats and B6C3F1 Mice(Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0,.05,.8, M: 0,.1,1.6 G/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C56097) Report Complete 
    • TR-395 (NTIS No. PB92-129584/AS)  (Peer Review 11/20/1990)
      Toxicology and Carcinogenesis Studies of Probenecid (CAS No. 57-66-9) in F344/N Rats and B6C3F1 Mice(Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: R&M:0,100,400 MG/KG/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (722868) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Salmonella  (518172) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • GD 7-14 Short-Term in vivo Repro. Tox. (Gavage)  (T0007A) Completed 
    • NTIS No. PB85-220143
      Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • F Mice: Swiss
    • Dose: 1200 MG/KG BODY WEIGHT
  • GD 6-15 (COPULATORY PLUG = GD 0) Short-Term in vivo Repro. Tox. (Gavage)  (T0007B) Completed 
    • F Mice: Swiss

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Web page last updated on January 22, 2009