Testing Status of Agents at NTP
2,3,7,8-Tetrachlorodibenzo-p-dioxin
CASRN: 1746-01-6
Related: TRANSGENIC MODEL EVALUATION (2,3,7,8-TETRACHLORODIBENZODIOXIN)
Formula: C12 H4 CL4 O2
Synonyms/Common Names:
- TCDD
- 2,3,7,8-TETRACHLORODIBENZO(B,E)(1,4)DIOXIN (9CI)
- 2,3,7,8-TETRACHLORODIBENZO-1,4-DIOXIN
Known Uses:
PRESENT IN CERTAIN HERBICIDE AND FUNGICIDE FORMULATIONS, SUCH AS 2,4,5-T AND PENTACHLOROPHENOLS; IT HAS BEEN TESTED FOR USE IN FLAMEPROOFING POLYESTERS & AGAINST INSECTS AND WOOD-DESTROYING FUNGI. A CONTAMINANT CREATED IN THE MFR OF AGENT ORANGE.
Short-Term Toxicity
- 14-Day (Gavage)
(C03714A) Completed
- NTIS No. PB82-163445
(Peer Review 06/27/1980)
Citation: Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS No. 1746-01-6) in Osborne-Mendel Rats and B6C3F1 Mice (Gavage Study) - Rats: Osborne Mendel; Mice: B6C3F1
- NTIS No. PB82-163445
(Peer Review 06/27/1980)
- 14-Day (Topical Application)
(C03714B) Completed
- NTIS No. PB82-163684
(Peer Review 06/27/1980)
Citation: Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS No. 1746-01-6) in Swiss-Webster Mice (Dermal Study) - Mice: Swiss Webster
- NTIS No. PB82-163684
(Peer Review 06/27/1980)
- 13-Week (Gavage)
(C03714A) Completed
- NTIS No. PB82-163445
(Peer Review 06/27/1980)
Citation: Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS No. 1746-01-6) in Osborne-Mendel Rats and B6C3F1 Mice (Gavage Study) - Rats: Osborne Mendel; Mice: B6C3F1
- Dose: R: 0,.5,8, M: 0,1,20 UG/KG/WK/10 PER GROUP
- NTIS No. PB82-163445
(Peer Review 06/27/1980)
- 13-WEEK (Topical Application)
(C03714B) Completed
- NTIS No. PB82-163684
(Peer Review 06/27/1980)
Citation: Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS No. 1746-01-6) in Swiss-Webster Mice (Dermal Study) - Mice: Swiss Webster
- Dose: 0,.005,10 UG/10 PER GROUP
- NTIS No. PB82-163684
(Peer Review 06/27/1980)
Long-Term Carcinogenicity
- 2-Year (Gavage)
(C03714A) Report Complete
- TR-209 (NTIS No. PB82-163445)
(Peer Review 06/27/1980)
Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS No. 1746-01-6) in Osborne-Mendel Rats and B6C3F1 Mice (Gavage Study) - Rats: Osborne Mendel; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Positive
- Female Mice Positive
- Dose: R&MM: 0,.01,.05,.5 UG/KG/WK/50 PER GROUP FM: 0,.04,.2,2.0 UG/KG/WK/50 PER GROUP
- TR-209 (NTIS No. PB82-163445)
(Peer Review 06/27/1980)
- 2-YEAR (Topical Application)
(C03714B) Report Complete
- TR-201 (NTIS No. PB82-163684)
(Peer Review 06/27/1980)
Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS No. 1746-01-6) in Swiss-Webster Mice (Dermal Study) - Mice: Swiss Webster
- Carcinogenesis Results
- Male Mice Equivocal
- Female Mice Positive
- Dose: FM: 0,.005, MM: 0,.001 UG/60 PER GROUP
- TR-201 (NTIS No. PB82-163684)
(Peer Review 06/27/1980)
Special Studies
- Absorption Disposition Metabolism Elimination (Topical Application)
(S0680) Completed
- Citation: BREWSTER, D.W., BANKS, Y.B., CLARK, A.M., BIRNBAUM, L.S., COMPARATIVE DERMAL ABSORPTION OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN & THREE POLYCHLORINATED DIBENZOFURANS: TOXICOLOGY & APPLIED PHARMACOLOGY 97, 156-166, 1989
- M Rats: F344/N
- Absorption Disposition Metabolism Elimination (Topical Application)
(S0684) Completed
- Citation: ANKS, Y.B., BREWSTER, D.W., & BIRNBAUM, L.S. AGE-RELATED CHANGES IN DERMAL ABSORPTION OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN AND 2,3,4,7,8-PENTACHLORODIBENZOFURAN FUNDAMENTAL & APPLIED TOXICOLOGY 15, 163-173, 1990
- M Rats: F344/N
- Absorption Disposition Metabolism Elimination (Topical Application)
(S0685) Completed
- Citation: BANKS, Y.B. & BIRNBAUM, L.S., ABSORPTION OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) AFTER LOW DOSE DERMAL EXPOSURE, TOXICILOGY & APPLIED PHARMACOLOGY, 107, 302-3210 (1991)
- M Rats: F344/N
- Dose: 1 nmol/kg
- Absorption Disposition Metabolism Elimination
(S0691) Completed
- Citation: HEBERT, C.D., & BIRNBAUM, L.S. THE INFLUENCE OF AGING ON INTESTINAL ABSORPTION OF TCDD IN RATS TOXICOLOGY LETTERS, 37, 47-55, 1987
- M Rats: F344/N
- Cell Proliferation
(S0692) Completed
- Citation: HEBERT ET AL. INHIBITION OF HIGH-DENSITY GROWTH ARREST IN HUMAN SQUAMOUS CARCINOMA CELLS BY 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) CARCINOGENESIS (LOND) 11:1335-1342, 1990. HEBERT ET AL. ROLE OF TRANSFERING GROWTH FACTOR B IN THE PROLIFERATIVE EFFECT OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN ON HUMAN SQUAMOUS CARCINOMA CELLS. CANCER RESEARCH 50, 7190-7197 11/15/90
- Human
- Mechanisms (Gavage)
(S0681) Completed
- Citation: HARRIS, MW., URAIH, L.C., BIRNBAUM, L.S. ACUTE TOXICITY OF PERFLUORODECANOIC ACID IN C57BL/6 MICE DIFFERS FROM 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN , FUNDAMENTAL & APPLIED TOXICOLOGY 13, 723-736, 1989
- F Mice: C57BL/6
- Dose: 0 to 320 mg/kg
- Mechanisms (Gavage)
(S0682) Completed
- Citation: ABBOTT, B.D., & BIRNBAUM, L.S., CELLULAR ALTERATIONS & ENHANCED INDUCTION OF CLEFT PALATE AFTER COADMINISTRATION OF RETINOIC ACID AND TCDD, TOXICOLOGY & APPLIED PHARMACOLOGY 99, 287-301, 1989
- M/F Mice: C57BL/6
- Mechanisms (Gavage)
(S0683) Completed
- Citation: BREWSTER, D.W. & BIRMBAUM, L.S. THE BIOCHEMICAL TOXICITY OF PERFLUORODECANOIC ACID IN THE MOUSE IS DIFFERENT FROM THAT OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TOXICOLOGY & APPLIED PHARMACOLOGY 99, 544-554, 1989
- F Mice: C57BL/6
- Dose: Ahb/b strain 0, 40, 80, 100, 120, 160 mk/kg: Ahb/d strain 0, 40, 80, 160 mg/kg: Ahd/d strain 0, 40, 80, 120 mk/kg
- Mechanisms (Topical Application)
(S0690) Completed
- Citation: STOHS, S.J., ABBOTT, B.D., LIN, F.H., & BIRNBAUM, L.S. INDUCTION OF ETHOXYRESORUFIN-O-DEETHYLASE AND INHIBITION OF GLUCOCORTICOID RECEPTOR BINDING IN SKIN AND LIVER OF HAIRED AND HAIRLESS HRS/J MICE BY TOPICALLY APPLIED TCDD TOXICOLOGY, 65, 123-136, 1990
- F Mice
- Dose: 12µg/kg
- Toxicokinetic Study (Gavage)
(S0621) Completed
- Citation: PART OF TWO YEAR TECHNICAL REPORT C96007G
- M/F Rats: Sprague Dawley
- Dose: FEMALE RATS: 0, 1, 3, 10, 30, 100 NG/KG MALE RATS TO BE USED AS SENTINELS.
Genetic Toxicology
- Chromosome Aberrations
(163229) Completed
- Mice
- Chromosome Aberation Negative
- In Vitro Cytogenetics (CA/SCE)
(764904) Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Chromosome Aberation Negative
- Sister Chromatid Exchange Negative
- Drosophila
(601370) Completed
- Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Mouse Lymphoma
(056688) Completed
- Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
- Negative
- Salmonella
(904370) Completed
- Citation: Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
- Negative
- Sister Chromatid Exchanges
(163229) Completed
- Mice
- Sister Chromatid Not Tested
Organ Systems Toxicity
- Immunotoxicity
(IMM95007) Completed
- Teratology Pilot Studies (Gavage & Intraperitoneal Injection)
(TRP92026) Completed
- M/F Mice: C57BL/6
- Dose: 0, 9, 12, OR 15 UG/KG + 10 MG/KG PYRAN
- Teratology Pilot Studies (Gavage & Intraperitoneal Injection)
(TRP92061) Completed
- M/F Mice: C57BL/6
- Dose: 0, 12, OR 15 UG/KG + PYRAN 0, 10, 50, OR 100 MG/KG
- Teratology Pilot Studies (Gavage & Intraperitoneal Injection)
(TRP92063) Completed
- M/F Mice: C57BL/6
- Dose: 0, 6, 12, OR 24 UG/KG TCDD; PYRAN 0, 10 MG/KG
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