National Toxicology Program

CASRN: 76-01-7

Related: HALOGENATED ETHANES CS (PENTACHLOROETHANE)

Formula: C2-H-CL5

Synonyms/Common Names:

• PENTALIN

Known Uses:

SOLVENT, CLEANSING AND DEGREASING METALS

Short-Term Toxicity

• 14-Day (Gavage)  (C53894) Completed 
  • NTIS No. PB83-206748  (Peer Review 06/23/1981)
    Citation: Carcinogenesis Studies of Pentachloroethane (CAS No. 76-01-7) in F344/N Rats and B6C3F1 Mice (Gavage Study)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C53894) Completed 
  • NTIS No. PB83-206748  (Peer Review 06/23/1981)
    Citation: Carcinogenesis Studies of Pentachloroethane (CAS No. 76-01-7) in F344/N Rats and B6C3F1 Mice (Gavage Study)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,5,250, M: 0,5,500 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C53894) Completed 
  • TR-232 (NTIS No. PB83-206748)  (Peer Review 06/23/1981)
    Carcinogenesis Studies of Pentachloroethane (CAS No. 76-01-7) in F344/N Rats and B6C3F1 Mice (Gavage Study)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Negative 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R: 0,75,150, M: 0,250,500 MG/KG/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (868606) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (818137) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Drosophila  (761216) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (072127) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Micronucleus  (A48831) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (926918) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Sister Chromatid Exchanges  (868606) Completed 
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol)