National Toxicology Program

CASRN: 100-02-7

Formula: C6-H5-N-O3

Synonyms/Common Names:

• 4-NITROPHENOL (9CI)

Known Uses:

INTERMEDIATE FOR INSECTICIDES. AZO AND SULFUR DYES. LEATHER PRESERVATIVES, FUNGICIDE (HSDB 1990)

Long-Term Carcinogenicity

• 2-YEAR (Topical Application)  (C55992B) Report Complete 
  • TR-417 (NTIS No. PB94-109667)  (Peer Review 07/09/1991)
    Toxicology and Carcinogenesis Studies of p-Nitrophenol (CAS No. 100-02-7) in Swiss Webster Mice (Dermal Studies)
  • Mice: Swiss Webster
  • Carcinogenesis Results
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: 0,40,80,175 MG/KG/60 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (333983) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Negative 
• Drosophila  (295493) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (616176) Completed 
  • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Salmonella  (158764) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 

Organ Systems Toxicity

• 8 CONS D (MTD PHASE), GD 7-14 (REPRO PHASE) Short-Term in vivo Repro. Tox. (Gavage)  (T0047) Completed 
  • NTIS No. PB83-213017
    Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
  • F Mice: Swiss
  • Dose: 400 MG/KG