National Toxicology Program

CASRN: 79-11-8

Formula: C2-H3-CL-O2

Synonyms/Common Names:

• ACETIC ACID, CHLORO- (8CI)(9CI)

Known Uses:

CHEMICAL INTERMEDIATE IN THE MANUFACTURE OF VARIOUS DYES AND OTHER ORGANIC MATERIALS. (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C60231) Completed 
  • NTIS No. PB92-189372  (Peer Review 11/20/1990)
    Citation: Toxicology and Carcinogenesis Studies of Monochloroacetic Acid (CAS No. 79-11-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C60231) Completed 
  • NTIS No. PB92-189372  (Peer Review 11/20/1990)
    Citation: Toxicology and Carcinogenesis Studies of Monochloroacetic Acid (CAS No. 79-11-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,30,150, M: 0,25,200 MG/KG/40 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C60231) Report Complete 
  • TR-396 (NTIS No. PB92-189372)  (Peer Review 11/20/1990)
    Toxicology and Carcinogenesis Studies of Monochloroacetic Acid (CAS No. 79-11-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0,15,30; M: 0,50,100 MG/KG/70 & 60 PER GROUP RESPECTIVELY

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (265221) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Drosophila  (255229) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive 
• Mouse Lymphoma  (486223) Completed 
  • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
  •  Positive 
• Salmonella  (910172) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Salmonella  (A15096) Completed 
  •  Negative