National Toxicology Program

CASRN: 77-47-4

Formula: C5-CL6

Synonyms/Common Names:

• 1,2,3,4,5,5-HEXACHLORO-1,3-CYCLOPENTADIENE (9CI)
• PERCHLOROCYCLOPENTADIENE

Known Uses:

CHEMICAL INTERMEDIATE FOR INSECTICIDES. FLAME RETARDANT. (TDB)

Short-Term Toxicity

• 13-WEEK (Inhalation)  (C55607B) Completed 
  • NTIS No. PB94-214186  (Peer Review 06/22/1993)
    Citation: Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CAS No. 77-47-4) in F344/N Rats and B6C3F1 Mice (inhalation studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,0.05,2.0 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C55607B) Report Complete 
  • TR-437 (NTIS No. PB94-214186)  (Peer Review 06/22/1993)
    Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CAS No. 77-47-4) in F344/N Rats and B6C3F1 Mice (inhalation studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R:0,.01,.05,.2PPM M:0,.01,.05,.2,.5PPM/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous; Gavage; Inhalation)  (S0029) Completed 
  • Citation: EL DAREER, S.M., NOKER, P.E., TILLERY, K.F. & HILL, D.L.: INVESTIGATIONS ON THE BASIS FOR THE DIFFERENTIAL TOXICITY OF HCPD ADMINISTERED TO RATS BY VARIOUS ROUTES, J TOXICOL & ENVIR HLTH, 12:203-211, 1983.
  • M Rats: F344/N; M Rats: F344/N; M Rats
  • Dose: PO:4.1,61;IV:0.59;INH:1.3 (6H),1.8(72H)MG/KG

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (353427) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (386002) Completed 
  • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (842404) Completed 
  • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Micronucleus  (A24947) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (725996) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Salmonella  (A66714) Completed 
  •  Negative