Testing Status of Agents at NTP
HC yellow 4
CASRN: 59820-43-8
Formula: C10-H14-N2-O5
Synonyms/Common Names:
- 2-((2-(2-HYDROXYETHOXY)-4-NITROPHENYL)AMINO)-ETHANOL
- YELLOW 4, HC
Known Uses:
IN SEMI-PERMANENT HAIR DYE FORMULATIONS (HSDB 1990).
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C56019) Completed
- NTIS No. PB93-123883
(Peer Review 07/09/1991)
Citation: Toxicology and Carcinogenesis Studies of HC Yellow 4 (CAS No. 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB93-123883
(Peer Review 07/09/1991)
- 13-Week (Dosed-Feed)
(C56019) Completed
- NTIS No. PB93-123883
(Peer Review 07/09/1991)
Citation: Toxicology and Carcinogenesis Studies of HC Yellow 4 (CAS No. 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,2500,20000 M: 0,5000,80000 PPM/10 PER GROUP
- NTIS No. PB93-123883
(Peer Review 07/09/1991)
Long-Term Carcinogenicity
- 2-YEAR (Dosed-Feed)
(C56019) Report Complete
- TR-419 (NTIS No. PB93-123883)
(Peer Review 07/09/1991)
Toxicology and Carcinogenesis Studies of HC Yellow 4 (CAS No. 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: MR: 0,0.25,0.5%, FR&M: 0,0.5,1.0%/70 PER GROUP
- TR-419 (NTIS No. PB93-123883)
(Peer Review 07/09/1991)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(203825) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- Drosophila
(048811) Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Sex-Linked Recessive Lethal Positive
- Reciprocal Translocation Negative
- Salmonella
(764380) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Positive
Web page last updated on January 22, 2009