Testing Status of Agents at NTP
Diethyl phthalate
CASRN: 84-66-2
Formula: C12-H14-O4
Synonyms/Common Names:
- 1,2-BENZENEDICARBOXYLIC ACID DIETHYL ESTER
- DEP
Known Uses:
IN MANUFACTURE OF CELLULOID, COSMETICS, VARNISHES, AND DOPES. PLASTICIZER FOR CELLULOSE ESTER PLASTICS. INSECTICIDE SPRAYS. (TDB)
Nomination Background
Short-Term Toxicity
- 4-WEEK (Topical Application)
(C60048B) Completed
- NTIS No. PB96-162276
(Peer Review 11/17/1993)
Citation: Toxicology and Carcinogenesis Studies of Diethylphthalate (CAS No. 84-66-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies) with Dermal Initiation/Promotion Study of Diethylphthalate and Dimethylphthalate (CAS No. 131-11-3) in Male Swiss (CD-1®) Mice - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB96-162276
(Peer Review 11/17/1993)
Long-Term Carcinogenicity
- 2-YEAR (Topical Application)
(C60048B) Report Complete
- TR-429 (NTIS No. PB96-162276)
(Peer Review 11/17/1993)
Toxicology and Carcinogenesis Studies of Diethylphthalate (CAS No. 84-66-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies) with Dermal Initiation/Promotion Study of Diethylphthalate and Dimethylphthalate (CAS No. 131-11-3) in Male Swiss (CD-1®) Mice - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice Equivocal Evidence
- Female Mice Equivocal Evidence
- Dose: R: 0,100,300 M: 0,7.5,15,30 UL/100 UL SOLUTION /50 PER GROUP
- TR-429 (NTIS No. PB96-162276)
(Peer Review 11/17/1993)
Special Studies
- Absorption Disposition Metabolism Elimination (Topical Application)
(S0044) Completed
- M Rats: F344/N
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(306322) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- In Vitro Cytogenetics (CA/SCE)
(913646) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- Salmonella
(364986) Completed
- Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
- Negative
- Salmonella
(576172) Completed
- Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
- Negative
Organ Systems Toxicity
- CONT EXPOS, 120 D MINIMUM Continuous Breeding (Dosed-Feed)
(RACB83092) Completed
- NTIS No. PB85-118636
Citation: Final Report - Diethyl Phthalate: Reproduction and Fertility Assessment In CD-1 Mice When Administered in the Feed - M/F Mice: Swiss
- Dose: N/A; 0,.25,1.25,2.5% IN FEED; N/A; 0,2.5%
- NTIS No. PB85-118636
- GD 7-14 Short-Term in vivo Repro. Tox. (Gavage)
(T0033A) Completed
- NTIS No. PB85-220143
Citation: Screening of Priority Chemicals for Potential Reproductive Hazard - F Mice: Swiss
- Dose: 4500 MG/KG BODY WEIGHT
- NTIS No. PB85-220143
- GD 6-15 Conventional Teratology (Dosed-Feed)
(TER88065) Completed
- NTIS No. PB89-140081
Citation: Developmental Toxicity Evaluation of Diethyl Phthalate Administered to CD Rats on Gestational Days 6 through 15? - F Rats: Sprague Dawley
- Rats Maternal Positive
- Rats Fetal Positive
- Dose: 0.25, 2.5, 5.0 %
- NTIS No. PB89-140081
Web page last updated on January 22, 2009