Testing Status of Agents at NTP
Turmeric, oleoresin (curcumin)
CASRN: 8024-37-1
Related: CURCURMIN (458-37-7)
Formula: C21-H20-O6
Synonyms/Common Names:
- CURCUMA LONGA OILS
- CURCUMA OIL
- Curcumin
- TURMERIC OIL
Known Uses:
CONDIMENT. COLOR FOR OINTMENTS. (1)
Short-Term Toxicity
- 13-Week (Dosed-Feed)
(C60015) Completed
- NTIS No. PB94-184173
(Peer Review 06/23/1992)
Citation: Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,.10,5%/10 PER GROUP
- NTIS No. PB94-184173
(Peer Review 06/23/1992)
Long-Term Carcinogenicity
- 2-YEAR (Dosed-Feed)
(C60015) Report Complete
- TR-427 (NTIS No. PB94-184173)
(Peer Review 06/23/1992)
Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats Equivocal Evidence
- Male Mice Equivocal Evidence
- Female Mice Equivocal Evidence
- Dose: R & M: 0, .2, 1.0, AND 5.0%
- TR-427 (NTIS No. PB94-184173)
(Peer Review 06/23/1992)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(001566) Completed
- Chromosome Aberation Weakly Positive
- Sister Chromatid Exchange Weakly Positive
- Salmonella
(857432) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Organ Systems Toxicity
- Continuous Breeding (Dosed-Feed)
(RACB85001) Completed
- M/F Rats/Mice: F344/N & B6C3F1
- Dose: 0, 2,000, 10,000, 50,000 PPM IN FEED
Web page last updated on January 22, 2009