Testing Status of Agents at NTP
Chlordecone (kepone)
CASRN: 143-50-0
Related: CHLORDECONE ALCOHOL (CAS 1034-41-9)
Formula: C10-Cl10-O
Synonyms/Common Names:
- 1,1A,3,3A,4,5,5A,5B,6-DECACHLOROOCTAHYDRO-1,3,4-METHENO-1H-CYCLOBUTA(CD)PENTALEN-2-OL (9CI)
- KEPONE
Known Uses:
INSECTICIDE FOR FRUIT TREES; AS A FUNGICIDE; BASE MATERIAL FOR THE MANUFACTURE OF KELEVAN.
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C00191) Completed
- NTIS No. PB264041
(Peer Review NA)
Citation: Report on Carcinogenesis Bioassay of Technical Grade Chlordecone (Kepone) (CAS No. 143-50-0) - Rats: Osborne Mendel; Mice: B6C3F1
- NTIS No. PB264041
(Peer Review NA)
- 13-Week (Dosed-Feed)
(C00191) Completed
- NTIS No. PB264041
(Peer Review NA)
Citation: Report on Carcinogenesis Bioassay of Technical Grade Chlordecone (Kepone) (CAS No. 143-50-0) - Rats: Osborne Mendel; Mice: B6C3F1
- NTIS No. PB264041
(Peer Review NA)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C00191) Report Complete
- TR-000 (143-50-0) (NTIS No. PB264041)
(Peer Review NA)
Report on Carcinogenesis Bioassay of Technical Grade Chlordecone (Kepone) (CAS No. 143-50-0) - Rats: Osborne Mendel; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Positive
- Female Mice Positive
- Dose: FR: 0,18,26 (AVG), MR: 0,8,24 (AVG), FM: 0,20,40 (AVG), MM: 0,20,23 (AVG) PPM
- TR-000 (143-50-0) (NTIS No. PB264041)
(Peer Review NA)
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage; Intravenous)
(S0447) Completed
- Citation: BUNGAY, P.M., DEDRICK, R.L., & MATTHEWS, H.B., ENTERIC TRANSPORT OF CHLORDECONE (KEPONE) IN THE RAT, J PHARM & BIOPHARM 9(3):309-341, 1981.
- Rats: Sprague Dawley; Rats: Sprague Dawley
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(232320) Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- Mouse Lymphoma
(163075) Completed
- Positive
- Salmonella
(663576) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
- Salmonella
(795821) Completed
- Negative
Organ Systems Toxicity
- Neurotoxicology Assessment
(NTA94020) Completed
- Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
- M/F Rats: F344/N
Web page last updated on January 22, 2009