National Toxicology Program

CASRN: 2244-16-8

Formula: C10-H14-O

Synonyms/Common Names:

• 2-METHYL-5-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-ONE (9CI)

Known Uses:

FOUND IN OIL OF CARAWAY, OTHER PLANTS; FLAVORING AGENT FOR FOOD & BEVERAGES; FRAGRANCE IN PERFUMERY & SOAPS (FOOD, COSM TOX. 1979)

Short-Term Toxicity

• 14-Day (Gavage)  (C55867A) Completed 
  • NTIS No. PB90-241100  (Peer Review 06/27/1989)
    Citation: Toxicology and Carcinogenesis Studies of d-Carvone (CAS No. 2244-16-8) in B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C55867A) Completed 
  • NTIS No. PB90-241100  (Peer Review 06/27/1989)
    Citation: Toxicology and Carcinogenesis Studies of d-Carvone (CAS No. 2244-16-8) in B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,93,1500 MG/KG/30 MALES PER GROUP/10 FEMALES PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C55867A) Report Complete 
  • TR-381 (NTIS No. PB90-241100)  (Peer Review 06/27/1989)
    Toxicology and Carcinogenesis Studies of d-Carvone (CAS No. 2244-16-8) in B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,175,375, M: 0,375,750 MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (983543) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Salmonella  (544172) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative